THE STRUCTURE AND FUNCTION OF HUMAN PHAGOCYTE FLAVOCYTOCHROME B

人吞噬细胞黄细胞色素B的结构和功能

• 批准号: 7602740
• 负责人: ALGIRDAS JOSEPH JESAITIS
• 金额: $ 1.79万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-13 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602740
• 关键词: Animals; Cell membrane; Chronic Granulomatous Disease; Computer Retrieval of Information on Scientific Projects Database; Disease; Electrons; Enzymes; Funding; Glycoproteins; Grant; Host Defense; Human; Individual; Infection; Inflammatory; Institution; Life; Membrane; Multienzyme Complexes; NADPH Oxidase; Phagocytes; Plants; Production; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; Superoxides; System; Transferase; United States National Institutes of Health; cytochrome b558; eosinophil; macrophage; monocyte; neutrophil; prototype; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flavocytochrome b is the central electron transferase of the NADPH oxidase of neutrophils, eosinophils, and monocytes/macrophages. This phagosomal and plasma membrane enzyme system is responsible for generating superoxide for host defense. Individuals deficient in this enzyme complex suffer severe life threatening infections with a disease called chronic granulomatous disease. Unregulated superoxide production is also pathogenic in a wide variety of inflammatory diseases. The flavocytochrome has also now been recognized to a prototype for NADPH oxidases widely expressed in plants and animals serving in oxidative signaling and organismic defense. The 3D structure of flavocytochrome b, an integral membrane heterodimeric glycoprotein, remains unknown.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 黄细胞色素B是中性粒细胞、嗜酸性粒细胞和单核细胞/巨噬细胞NADPH氧化酶的中心电子转移酶。这种吞噬体和质膜酶系统负责产生超氧化物用于宿主防御。 缺乏这种酶复合物的个体患有严重的威胁生命的感染，这种疾病称为慢性肉芽肿病。不受调节的超氧化物产生也是多种炎性疾病的致病性。黄细胞色素现在也被认为是NADPH氧化酶的原型，在植物和动物中广泛表达，在氧化信号和器官防御中发挥作用。黄素细胞色素B是一种完整的膜异源二聚体糖蛋白，其三维结构尚不清楚。