Core--Environmental Molecular Analysis
核心--环境分子分析
基本信息
- 批准号:7064120
- 负责人:
- 金额:$ 23.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-01 至 2011-03-31
- 项目状态:已结题
- 来源:
- 关键词:aromatic hydrocarbon receptorbenzofuransbioinformaticsbiomedical facilitybiotechnologycarbopolycyclic compounddioxinsenvironmental contaminationgenetic libraryhalobiphenyl /halotriphenyl compoundhigh throughput technologymathematical modelmicroarray technologymodel design /developmentmolecular biologynucleic acid sequencepolymerase chain reaction
项目摘要
Molecular technologies have become key to a more in-depth understanding of the complex processes and
interactions of microbial communities, and are especially important to a mechanistic understanding of
bioremediation processes. New tools are constantly being developed to aid this objective but their
application and optimization to microbial research under environmentally relevant conditions is not easy.
Our overall goal is to use and enhance these technologies for understanding how microbes react to
environmental changes in situ rather than simply as laboratory pure cultures. This can best be done by a
support core with interacting components. We will develop new tools and
discover new genes involved in degradation of polyaromatic compounds. This process will require the
support of a variety of enabling technologies, the most central of which are provided and optimized in this
support core. The specific aims of this core proposal are to provide needed support in three related areas:
(1) microarray development and enhancement, (2) automated bioinformatic analyses of PCR product
sequences and biodegradative gene clusters, and (3) high throughput screening and sequencing of
environmental clones. The project brings together the strengths of a multidisciplinary team of researchers,
each one acting in their own areas of expertise. The Center for Microbial Ecology (CME) and the
Department of Civil and Environmental Engineering at Michigan State University has developed a microarray
platform that will support our proposed genomic analyses. CME's Microbial Informatics Group manages the
Ribosomal Database Project and has developed a bioinformatic platform for sequence analyses and other
data analysis tools. The Biotechnology Center for Agriculture and the Environment at Rutgers University has
developed a high throughput screening facility with an emphasis on screening cultures and clones. These
three components will form an interacting triad supporting the environmental research projects, and will
exchange at a general level strategies and concepts with the Biomedical Informatics core and toxicology
projects that use genetic and microarray array technologies.
分子技术已经成为更深入地了解复杂过程的关键
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GERBEN J ZYLSTRA其他文献
GERBEN J ZYLSTRA的其他文献
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{{ truncateString('GERBEN J ZYLSTRA', 18)}}的其他基金
Molecular Insight into Toxicant Degradation by Microbial Communities
微生物群落有毒物质降解的分子洞察
- 批准号:
7596967 - 财政年份:2007
- 资助金额:
$ 23.1万 - 项目类别:
Molecular Insight into Toxicant Degradation by Microbial Communities
微生物群落有毒物质降解的分子洞察
- 批准号:
7459914 - 财政年份:2007
- 资助金额:
$ 23.1万 - 项目类别:
Molecular Insight into Toxicant Degradation by Microbial Communities
微生物群落有毒物质降解的分子洞察
- 批准号:
7290870 - 财政年份:2007
- 资助金额:
$ 23.1万 - 项目类别:
ELECTRON TRANSFER BETWEEN TOLUENE DIOXYGENASE COMPONENTS
甲苯双加氧酶组分之间的电子转移
- 批准号:
3044120 - 财政年份:1989
- 资助金额:
$ 23.1万 - 项目类别:
ELECTRON TRANSFER BETWEEN TOLUENE DIOXYGENASE COMPONENTS
甲苯双加氧酶组分之间的电子转移
- 批准号:
3044121 - 财政年份:1988
- 资助金额:
$ 23.1万 - 项目类别:
Project 5: Molecular Insight into Dioxin Degradation by Microbes and Microbial
项目 5:微生物和微生物降解二恶英的分子洞察
- 批准号:
8564240 - 财政年份:
- 资助金额:
$ 23.1万 - 项目类别:
Project 5: Molecular Insight into Dioxin Degradation by Microbes and Microbial
项目 5:微生物和微生物降解二恶英的分子洞察
- 批准号:
8695355 - 财政年份:
- 资助金额:
$ 23.1万 - 项目类别:
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