STRUCTURE AND FUNCTION OF PYK2 IN INTEGRIN SIGNALING

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的长期目标是了解PYK2在破骨细胞激活过程中整合素信号转导中的结构生物学和功能，探索其结构、功能和动力学之间的关系，并利用这种关系特异性地抑制骨溶解所需的PYK2。为此，我们开展了一项合作研究工作，通过X射线结晶学研究PYK2的三维结构以及PYK2对相关蛋白质的分子识别作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal of the proposed research is to understand the structural biology and function of PYK2 in the integrin signaling during osteoclast activation, explore the relationship among its structure, function and dynamics, and exploit this relation for specific inhibition of PYK2 required for osteolysis. Towards this goal, we have initiated a collaborative research effort to study the three-dimensional structure of PYK2 by X-ray crystallography and the molecular recognition of the associated proteins by PYK2.