M TUBERCULOSIS ADENOSINE KINASE AND ANTI-MICROBIAL NUCLEOSIDE ANALOGS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这些项目的总体目标是研究结核分枝杆菌（一种导致结核病的机会致病菌）中叶酸生物合成和核苷补救途径中酶的晶体结构，并将这些酶开发为治疗结核病的治疗靶点。 我们已经获得了这些途径中的一些关键酶的晶体，包括二氢叶酸还原酶和腺苷激酶与它们的底物或底物类似物的复合物。 蛋白质复合物的晶体结构将为开发高效和选择性抗M的新型化合物提供分子基础。结核病，并可能用于结核病治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the projects is to study the crystal structure of the enzymes from the pathway of folate biosynthesis and nucleoside salvage in Mycobacterial tuberculosis, an opportunistic pathogen that causes TB and to develop these enzymes as therapeutic targets to treat TB. We have obtained crystals of some the key enzymes in these pathways, including dihydrofolate reductase and adenosine kinase in complexes with their substrate or substrate analogs. The crystal structure of the protein complexes will provide the molecular basis for developing novel compounds that are highly potent and selective against M. tuberculosis and are potentially useful for the TB treatment.