Retinal drive of spontaneous system activity

自发系统活动的视网膜驱动

• 批准号: 7394943
• 负责人: Matthew Todd Colonnese
• 金额: $ 4.7万
• 依托单位: INSERM UNIT 29
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-15 至 2009-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394943
• 关键词: Action Potentials; Adult; Anesthesia procedures; Arousal; Behavior; Biological Pacemakers; Birth; Brain; Chemosensitization; Chronic; Development; Electric Stimulation; Electrodes; France; Frequencies; Generations; Implant; Laboratories; Lateral Geniculate Body; Localized; Mammals; Maps; Methods; Modeling; Muscle; Neocortex; Neonatal; Neurons; Neuropil; Newborn Animals; Pattern; Perinatal; Physiology; Range; Rattus; Retina; Retinal; Retinal Ganglion Cells; Role; Sensory; Silicon Dioxide; Sleep; Somatosensory Cortex; Structure; Synapses; Synaptic plasticity; System; Testing; Thalamic Nuclei; Thalamic structure; Time; Travel; Vision; Visual; Visual Cortex; Visual system structure; Week; Whole-Cell Recordings; Work; area striata; awake; day; driving force; experience; extracellular; ganglion cell; in vivo; interest; langanite; neonate; research study; retinotopic; size; superior colliculus Corpora quadrigemina

The patterns of activity in the brains of neonates, though it is critical for the normal development of synaptic connectivity, is largely unknown. Recent work has shown that in the cortex of neonatal rats, nearly all neuronal activity consists of bursts of synchronous oscillatory activity similar to spindle waves observed in adults during sleep. In the somatosensory cortex these bursts are correlated with spontaneous muscle jerks and sensory input. How precisely such correlation comes about will be important to understand how different regions coordinate activity in the time before normal sensory input develops. The visual system is an excellent model in which to study this question. Much of the organization of the visual system occurs before vision, driven by spontaneous bursts of activity in retinal ganglion cells. Through a combination of paired recordings, pharmacological manipulation of the retina, and electrical stimulation, the experiments in this proposal will discern if retinal activity patterns activity in the major visual targets, or if it acts to trigger endogenous oscillators centrally. This information will aid in the development of accurate models of activity dependent development.

新生儿大脑中的活动模式，尽管它对突触的正常发育至关重要， 连通性在很大程度上是未知的。最近的研究表明，在新生大鼠的皮层中，几乎所有的 神经元活动包括同步振荡活动的爆发，类似于在 成年人在睡眠中在躯体感觉皮层中，这些爆发与自发的肌肉痉挛相关 和感官输入这种相关性是如何精确地产生的，对于理解这种相关性是如何产生的非常重要。 在正常感觉输入发展之前，不同区域协调活动。视觉系统是 一个很好的模型来研究这个问题。视觉系统的大部分组织 由视网膜神经节细胞的自发活动驱动。通过结合 配对记录、视网膜的药理学操作和电刺激，这些实验 这项建议将辨别视网膜活动模式是否在主要视觉目标中活动，或者它是否起触发作用， 内源性振荡器居中。这一信息将有助于制定准确的活动模型 依赖发展。