Perceived Cognitive function Item Bank for Children Who Undergo Cancer Treatment

接受癌症治疗的儿童的感知认知功能项目库

• 批准号: 7315984
• 负责人: JIN-SHEI LAI
• 金额: $ 33.72万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7315984
• 关键词: 15 year old; Accounting; Acute; Address; Adolescent; Adult; Adverse effects; Aftercare; Age; Age-Years; Brain Neoplasms; Cancer Patient; Cancer Survivorship; Cause of Death; Child; Childhood; Children' s Oncology Group; Clinical; Condition; Development; Discrimination; Disease; Early identification; Ensure; Family; Foundations; Funding; Generic Drugs; Goals; Graph; Guidelines; Health Status; Individual; Information Systems; Institutes; Intervention; Late Effects; Lead; Length; Libraries; Life Style; Literature; Longevity; Lymphoblastic Leukemia; Lymphocyte; Malignant Childhood Neoplasm; Malignant Neoplasms; Measurement; Measures; Medical Technology; Metric; Modeling; Monitor; Neurocognitive; Neurocognitive Deficit; Neuropsychological Tests; Numbers; Parents; Patient Monitoring; Patient Outcomes Assessments; Patient Self-Report; Patients; Population; Property; Proxy; Psychometrics; Rate; Receiver Operating Characteristics; Reporting; Research; Research Personnel; Score; Screening procedure; Staging; Survivors; System; Testing; Time; United States; United States National Institutes of Health; Validity and Reliability; age group; base; cancer therapy; childhood cancer survivor; cognitive function; computerized; experience; follow-up; neuropsychological; programs; psychosocial; response; sound; theories; tool; treatment effect; user-friendly

DESCRIPTION (provided by applicant): Lifelong decrements in neurocognitive function (NF) are among the most prominent concerns for childhood cancer survivors, which can result in psychosocial problems of survivors and extend to the entire family. Routine assessment is especially critical for survivors as NF deficits may first appear years after the treatment. Current NF assessment relies on neuropsychological test battery, which is lengthy, expensive, and produces practice effects if it is administered routinely. Given these obstacles, there is a need for a measurement system that can provide brief and precise assessments tailored to the individual, thereby making it possible to screen patients who need comprehensive neuropsychological testing in busy clinical settings. To address this need, we propose to develop a comprehensive perceived cognitive function item bank (PCF) for children 7-21 years of age, which facilitates the development of individualized computerized adaptive testing (CAT) and short-forms that can serve as the screening tool. This bank would augment an existing adult PCF bank thereby providing the basis for psychometrically sound assessment across the disease continuum and life span. We propose the development of a parent proxy version for children of all ages and a self-reported version for children ages 1.3-21. The development of the pedsPCF bank will be accomplished through the successful completion of the following three aims. Aim 1 is to generate a perceived cognitive function item pool for the pediatric population. We will develop this pool by reviewing items from the existing adultPCF bank, an item library that we have built within the scope of two federally funded projects, and current literature. Items will be rigorously reviewed by clinicians, children and parents for their content validity. New items will be added to reflect developmental differences as necessary to ensure the comprehensiveness of the pool. Aim 2 is to examine the psychometric properties of the pedsPCF item bank(s) via the completion of two sub-aims: a) evaluate the essential unidimensionality of the pedsPCF bank; and b) calibrate the item bank(s) using item response theory (IRT) models. Aim 3 is to examine the clinical usefulness of the pedsPCF item bank(s) in relation to external clinical criteria. This includes: a) using discriminant function analysis and receiver operating characteristic curve approaches to establish cut scores; b) using IRT to develop user-friendly short-forms in screening patients for comprehensive testing; and c) using both anchored and distribution based approaches to identify minimally important differences in PCF. With the completion of this project, we hope to reach our ultimate goal of developing a measurement system that 1) can monitor patient perceived cognitive function throughout developmental stages, 2) can serve as the foundation for CAT and short-forms, which can then serve as a clinically meaningful screening tool.

描述（由申请人提供）：神经认知功能（NF）的终身衰退是儿童癌症幸存者最突出的问题之一，这可能导致幸存者的心理社会问题并扩展到整个家庭。常规评估对于幸存者尤其重要，因为NF缺陷可能在治疗后数年首次出现。目前的NF评估依赖于神经心理测试电池，这是漫长的，昂贵的，并产生实践效果，如果它是常规管理。考虑到这些障碍，需要一种测量系统，该测量系统可以提供针对个体定制的简短而精确的评估，从而使得可以在忙碌的临床环境中筛选需要全面神经心理学测试的患者。为了满足这一需求，我们建议为7-21岁儿童开发一个全面的感知认知功能项目库（PCF），这有助于开发个性化的计算机自适应测试（CAT）和可作为筛查工具的简短表格。这个银行将增加现有的成人PCF银行，从而提供了心理健康评估的基础上，整个疾病的连续性和寿命。我们建议为所有年龄段的儿童开发一个家长代理版本，并为1.3-21岁的儿童开发一个自我报告版本。pedsPCF银行的发展将通过以下三个目标的成功完成来实现。目的1是为儿科人群生成感知认知功能项目库。我们将通过审查现有的adultPCF银行，项目库，我们已经建立了两个联邦资助的项目范围内的项目，和当前的文献，开发这个池。项目将严格审查临床医生，儿童和家长的内容有效性。必要时将增加新的项目，以反映发展差异，确保汇总表的全面性。目的2是通过完成两个子目的来检查pedsPCF题库的心理测量学特性：a）评估pedsPCF题库的基本一维性;和B）使用项目反应理论（IRT）模型校准题库。目的3是检查与外部临床标准相关的pedsPCF项目库的临床有用性。这包括：a）使用判别函数分析和受试者工作特征曲线方法来建立切割分数; B）使用IRT来开发用于筛选患者以进行全面测试的用户友好的简表;以及c）使用锚定和基于分布的方法来识别PCF中的最小重要差异。随着这个项目的完成，我们希望达到我们的最终目标，即开发一个测量系统，1）可以在整个发育阶段监测患者感知的认知功能，2）可以作为CAT和简短形式的基础，然后可以作为临床上有意义的筛选工具。