LINKING DEPRESSION WITH INCREASED MORBIDITY AND MORTALITY IN PATIENTS W HF

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是探索抑郁症与心力衰竭(HF)发病率和死亡率增加之间已知关联的这两种潜在机制。这项研究的特殊目的是确定交感神经系统(SNS)的唤醒和不坚持是否都有助于抑郁症和较差的心衰结局之间的联系。这一目标将在一项前瞻性的相关性研究中得到验证，在这项研究中，将测试DND唤醒和不坚持对抑郁和心力衰竭患者预后之间关系的中介作用。共有300名确诊为慢性心力衰竭的患者因左心室收缩功能受损的缺血性病因而接受随访。这项研究的结果将为临床医生和研究人员设计有效的干预措施提供有关抑郁症和不良结局的机制的重要信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to explore these two potential mechanisms for the known association between depression and increased morbidity and mortality in Heart Failure (HF). The specfic aim for this study is to determine whether both Sympathetic nervous system (SNS) arousal and nonadherence contribute to the association between depression and poorer HF outcomes. This aim will be tested in a prospective correlational study in which the mediating effects of both DND arousal and nonadherence on the association between depression and the HF patient outcomes will be tested. A total of 300 patients with a confirmed diagnosis of chronic HF from an ischemic etiology with impaired left ventricular systolic function will be followed. Results of this study will provided vital information about the mechanisms linking depression and poor outcomes that clinicians and researchers can use in the design of effective intervention