LINKING DEPRESSION WITH INCREASED MORBIDITY AND MORTALITY IN PATIENTS W HF

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是探讨抑郁症与心力衰竭 (HF) 发病率和死亡率增加之间已知关联的两种潜在机制。本研究的具体目的是确定交感神经系统 (SNS) 唤醒和不依从是否会导致抑郁症和较差的心力衰竭结局之间的关联。这一目标将在一项前瞻性相关研究中得到检验，其中将检验 DND 唤醒和不依从性对抑郁和心力衰竭患者预后之间关联的中介作用。总共有 300 名确诊为缺血性慢性心力衰竭且左心室收缩功能受损的患者将接受随访。这项研究的结果将提供有关抑郁症与不良结局之间联系机制的重要信息，临床医生和研究人员可以利用这些信息来设计有效的干预措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to explore these two potential mechanisms for the known association between depression and increased morbidity and mortality in Heart Failure (HF). The specfic aim for this study is to determine whether both Sympathetic nervous system (SNS) arousal and nonadherence contribute to the association between depression and poorer HF outcomes. This aim will be tested in a prospective correlational study in which the mediating effects of both DND arousal and nonadherence on the association between depression and the HF patient outcomes will be tested. A total of 300 patients with a confirmed diagnosis of chronic HF from an ischemic etiology with impaired left ventricular systolic function will be followed. Results of this study will provided vital information about the mechanisms linking depression and poor outcomes that clinicians and researchers can use in the design of effective interventions.