GESTATIONAL DIABETES MELLITUS: IMPACT ON ORAL HEALTH

妊娠期糖尿病：对口腔健康的影响

• 批准号: 7379036
• 负责人: Karen F. Novak
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379036
• 关键词: GESTATIONAL; DIABETES; MELLITUS; IMPACT; ORAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. General hypothesis is that women with GDM are at higher risk for developing more severe periodontal disease than women without GDM and that the combination of GDM and periodontal disease will be associated with an increased negative impact on maternal and fetal health. The following Specific Aims are designed to address this question. To Characterize the prevalence, extent and severity of of periodonitis and associations between periodontits and adverse maternal and fetal outcomes in women who develop GDM compared to women who don't develop GDM. Aim 2 will characterize the subgingival microbial ecology in women with GDM and periodontal disease and determine if specific microbial characteristics are associated with adverse pregnancy and fetal outcomes. Aim 3 will determine if patients with GDM and periodontitis have elevated levels of circulating inflammatory mediators comaper to women with GDM and no periodonititis and the non-GDM controls.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。一般的假设是，GDM女性比没有GDM的女性患更严重牙周病的风险更高，GDM和牙周病的结合将与对孕产妇和胎儿健康的负面影响增加有关。以下具体目标旨在解决这一问题。描述发生GDM的女性与未发生GDM的女性相比，牙周炎的患病率、范围和严重程度以及牙周炎与不良母婴结局之间的关系。目的2将描述GDM和牙周病妇女的龈下微生物生态学特征，并确定特定的微生物学特征是否与不良妊娠和胎儿结局相关。目的3将确定GDM和牙周炎患者是否具有与GDM和非牙周炎的女性以及非GDM对照相比的循环炎症介质水平升高。