INFLAMMATION AND INSULIN RESISTANCE IN PERIPHERAL ARTERY DISEASE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是探讨为什么静脉旁路移植发展这种狭窄。有证据表明，血管阻塞的发展可能与身体对血液中循环的糖和炎症标志物的调节异常有关。我们将研究这些标记物是否与手术后旁路移植物中发生的变化有关。随着时间的推移，静脉移植物的超声研究和/或磁共振成像（MRI）将帮助我们了解导致某些静脉移植物再狭窄的因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to examine why vein bypass grafts develop this narrowing. Evidence suggests that the development of blockages in blood vessels may be linked to abnormalities in the body's regulation of sugar and markers of inflammation that circulate in the blood. We will be studying if these markers are related to changes that occur in the bypass graft after surgery. Ultrasound studies and/or magnetic resonance imaging (MRI) of the vein graft over time will help us understand the factors that cause some vein grafts to re-narrow.