IRREVERSIBLE AIRWAY DISEASE IN ASTHMA: EXHALED BREATH

哮喘中的不可逆气道疾病：呼气

• 批准号: 7375832
• 负责人: N FRANKLIN ADKINSON
• 金额: $ 1.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375832
• 关键词: IRREVERSIBLE; AIRWAY; DISEASE; ASTHMA; EXHALED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overarching goal of this research is to understand the pathophysiology and natural history of childhood asthma. A small portion of childhood asthmatics develop evidence of lung function impairment that is resistant to pharmacotherapy that may be due to irreversible airway disease. The central hypothesis is that young adults with irreversible airway disease may be differentiated from control asthmatics by structural and pathophysiological changes demonstrated by CT and increased methacholine airway sensitivity but not on the basis of induced sputum or EBC. This descriptive, pilot study seeks to employ two novel, non-invasive techniques exhaled breath condensates (EBC) and induced sputum (IS) to study airway remodeling and inflammation in asthma. Samples collected from 40 asthmatic adults and 40 age-matched controls will provide EBS and IC samples. The samples will be analyzed for markers of airway inflammation and remodeling. In addition several methodologic issues will be analyzed including diurnal variation, intra-subject reproducibility, between subject variance for asthmatic and normal subjects, optimal sampling time.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究的首要目标是了解儿童哮喘的病理生理学和自然史。一小部分儿童哮喘患者出现肺功能损害的证据，这种肺功能损害对药物治疗有抵抗力，这可能是由于不可逆的气道疾病。 中心假设是，不可逆的气道疾病的年轻成人可能会从控制哮喘的CT和乙酰甲胆碱气道敏感性增加，而不是诱导痰或EBC的基础上显示的结构和病理生理变化进行区分。 这项描述性的初步研究旨在采用两种新的非侵入性技术呼出气冷凝物（EBC）和诱导痰（IS）来研究哮喘的气道重塑和炎症。从40名哮喘成人和40名年龄匹配的对照中采集的样本将提供EBS和IC样本。将分析样本的气道炎症和重塑标志物。此外，还将分析几个方法学问题，包括昼夜变化、受试者内重现性、哮喘和正常受试者的受试者间方差、最佳采样时间。