LUNG CHANGES IN YOUNG ADULTS WITH MODERATE TO SEVERE ASTHMA-HRCT SCANS, METHACHS

患有中度至重度哮喘的年轻人的肺部变化-HRCT 扫描、方法

• 批准号: 7375837
• 负责人: N FRANKLIN ADKINSON
• 金额: $ 1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375837
• 关键词: LUNG; CHANGES; YOUNG; ADULTS; MODERATE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Childhood Asthma Study (CAS), a randomized, masked, placebo controlled trial of broad spectrum allergen immunotherapy, identified a group of young adults with moderate to severe asthma who now have persistent lung function deficits. In order to characterize the nature of these functional deficits further, these investigators propose a three part study to examine the lung anatomy and pathophysiology in these subjects including high resolution CT scanning of the airways (HRCT), methacholine challenge tests, and induced sputum (IS) and exhaled condensate studies (EBC). These investigators hypothesize that subjects with persistent lung function deficits will be distinguishable from other cohort member by evidence of increased airway thickening and reduced distensibility on CT scans, increased airway hyperreactivity as expressed by methacholine sensitivity, and increased inflammatory markers on IS and EBC sampling. These studies have important implications for monitoring and prognosis of childhood asthma.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。儿童哮喘研究（CAS）是一项随机、隐蔽、安慰剂对照的广谱过敏原免疫治疗试验，确定了一组患有中度至重度哮喘的年轻人，他们现在有持续的肺功能缺陷。为了进一步表征这些功能缺陷的性质，这些研究人员提出了一项由三部分组成的研究，以检查这些受试者的肺部解剖和病理生理学，包括气道高分辨率CT扫描（HRCT）、甲胆碱激发试验、诱导痰（IS）和呼出冷凝水研究（EBC）。这些研究人员假设，通过CT扫描显示气道增厚和扩张性降低、甲胆碱敏感性表现的气道高反应性增加以及IS和EBC样本中炎症标志物增加，可以将持续肺功能缺陷的受试者与其他队列成员区分出来。这些研究对儿童哮喘的监测和预后具有重要意义。