NSABP B-27:TRIAL COMPARING PREOP AC TO AC FOLLOWED BY TAXOTERE/CANCER OF BREAST

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的主要目的是确定术前4个周期AC后给予术前4个周期或术后4个周期泰索帝是否比术前单独4个周期AC更有效地延长无病生存期和生存期。本研究还将评估术前AC术后给予泰索帝对临床和病理局部区域肿瘤反应和乳房保护的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aim of this study to determine whether 4 cycles of preoperative or postoperative Taxotere given after 4 cycles of preoperative AC will more effectively prolong disease-free survival and survival than do 4 cycles of pre-operative AC alone. This study will also evaluate the effect of the administration of pre-operative Taxotere after preoperative AC with respect to clinical and pathologic loco-regional tumor response and breast conservation.