NSABP B-27:TRIAL COMPARING PREOP AC TO AC FOLLOWED BY TAXOTERE/CANCER OF BREAST

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aim of this study to determine whether 4 cycles of preoperative or postoperative Taxotere given after 4 cycles of preoperative AC will more effectively prolong disease-free survival and survival than do 4 cycles of pre-operative AC alone. This study will also evaluate the effect of the administration of pre-operative Taxotere after preoperative AC with respect to clinical and pathologic loco-regional tumor response and breast conservation.