Workshop on Musculoskeletal Biology at the 50th Annual Meeting of the Orthopedic Research Society; Midway, Utah; 22-27 July 2023

该奖项将为初级研究人员提供差旅支持，以参加2023年7月22-27日在犹他州中途举行的第50届整形外科研究学会(ORS)年会上的肌肉骨骼生物学研讨会。这一研讨会促进了生物学家、工程师和临床医生在肌肉骨骼生物学、生物力学和机械生物学领域的跨学科交流；促进了各级研究人员在其职业生涯中的互动；建立了终身科学网络；强调初级教职员工和学生的积极参与；并且独特之处在于讨论时间等于或超过了演讲时间。研讨会的重点是广泛的、高度多学科的。会议讨论了当前的重大问题、局限性、潜在的解决方案和适用于基础科学和临床的方法。参加这一讲习班的有相当数量的学生、青年调查人员、妇女和代表性不足的少数群体。与ORS的合作关系通过广播电子邮件和ORS网站上的链接提供最大的可见度，摘要将张贴在ORS网站上。2023年研讨会的科学主题是“肌肉骨骼细胞：识别、靶向、刺激和治疗收益的操纵”。会议将讨论当前的重大问题、限制和潜在的解决方案，以及适用于临床和基础科学的方法。全会讲座“骨的重塑”(RIB)的题目是“骨机械生物学：利用骨骼负荷的力量”。六场科学会议将涵盖(1)从单细胞组学技术对骨关节炎发病机制的新见解；(2)骨骼干细胞/祖细胞；(3)工作中的成像机械生物学；(4)破骨细胞：起源和命运；(5)结缔组织靶向：向肌肉骨骼组织输送分子；以及(6)罕见骨和矿物疾病的分子病理生理学如何为治疗和生物学提供信息。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award will provide travel support for junior investigators to attend the Workshop on Musculoskeletal Biology at the 50th Annual Meeting of the Orthopedic Research Society (ORS); Midway, Utah; 22-27 July 2023. This workshop promotes interdisciplinary communication among biologists, engineers, and clinicians in the area of musculoskeletal biology, biomechanics and mechanobiology; stimulates interactions among investigators in all levels in their careers; builds for-life scientific networks; emphasizes active participation of junior faculty and students; and is unique in that discussion time equals or exceeds time allotted for presentations. The focus of the workshop is broad and highly multidisciplinary. Sessions address significant current problems, limitations, potential solutions, and approaches applicable to both basic science and clinical. The attendance of this Workshop represents a significant number of students, young investigators, women, and underrepresented minorities. Partnership with the ORS provides maximum visibility through broadcast emails and links on the ORS website, where abstracts will be posted.The scientific theme of the 2023 workshop is "Musculoskeletal cells: identity, targeting, stimulation, and manipulation for therapeutic gain." Sessions will address significant current problems, limitations and potential solutions, and approaches applicable to both clinical and basic science. The Plenary Lecture “Remodeling in Bone” (RIB) is entitled “Bone mechanobiology: harnessing the power of skeletal loads.” Six scientific sessions will cover (1) New insights into osteoarthritis pathogenesis from single-cell -omic technologies; (2) Skeletal stem/progenitor cells; (3) Imaging mechanobiology at work; (4) Osteoclasts: origin and fate; (5) Connective tissue targeting: delivering molecules to musculoskeletal tissues; and (6) How the molecular pathophysiology of rare bone and mineral diseases informs treatment and biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.