ANGIOGENIC ENDOTHELIAL CELL DETECTION IN PERIPHERAL CIRCULATION IN METASTATIC DS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a voluntary research study to see if a simple blood test can detect the presence of a gene in the blood which may be produced only by cancer cell blood vessels. Approximately 60 subjects will be enrolled into this study. There will be three groups of subjects. There will be 20 subjects that will consist of healthy individuals, 20 subjects with cancer that has spread from one area to another in the body and 20 subjects will be receiving treatment with a study drug called Octreother. Subjects in the first two groups will donate approximately 5cc of blood on one occasion. Subjects undergoing treatment with Octreother will donate approximately 5cc of blood prior to treatment and one after each treatment with Octreother (maximum three teaspoons).