PROPOFOL VERSUS PROPOFOL-FENTANYL AS SEDATION FOR LUMBAR PUNCTURE IN CHILDREN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。两种不同的镇静方案用于诊断性和治疗性腰椎穿刺治疗癌症儿童正在研究安全性和有效性的目的。患有急性白血病的儿童每年至少要接受10次侵入性治疗。研究表明，癌症儿童的程序性疼痛控制是癌症治疗中最重要的方面之一。事实上，研究表明，癌症儿童的程序性疼痛控制不佳与抑郁症和焦虑症的发展有关。此外，较差的手术疼痛控制导致在以后的手术中更难控制疼痛。因此，美国儿科学会（American Academy of Pediatrics）建议，对患有癌症的儿童进行积极的程序性疼痛控制是癌症治疗的一个组成部分。我们研究的主要目的是找出两种镇静方案中哪一种对接受腰椎穿刺手术的癌症儿童最安全。孩子们将被监测他们的氧气水平、血压和心率。我们的计划是研究40名患有急性白血病或淋巴瘤的儿童。以随机方式对每个儿童进行两次研究，以便对每种镇静方案的安全性和有效性进行一次评估。在研究期结束时，评估每个方案的安全性和有效性概况。如果两种方案都同样安全，那么家庭和儿童就可以在未来的侵入性手术中选择他们更喜欢的方案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Two different sedative regimens for diagnostic and therapeutic lumbar punctures conducted on children with cancer are being studied for safety and efficacy purposes. Children with acute leukemia undergo at least 10 invasive procedures per year for their cancer treatment. Research has shown that procedural pain control in children with cancer is one of the most important aspects of their cancer treatment. Indeed, studies have shown that poorly controlled procedural pain in children with cancer is associated with the development of depression and anxiety disorders. Also, poor procedural pain control leads to more difficulty in controlling pain for future procedures. Consequently, the American Academy of Pediatrics has recommended that aggressive procedural pain control in children with cancer be an integral part of cancer treatment. Our study's primary purpose is to find which of two sedative regimens is safest for a child with cancer undergoing lumbar puncture procedures. Children will be monitored for their oxygen levels, blood pressure and heart rate. Our plan is to study 40 children with acute leukemia or lymphoma. Each child is studied twice in a randomized manner so that the safety and efficacy of each sedative regimen is evaluated once. At the end of the study period, the safety and efficacy profiles of each regimen are evaluated. If both regimens are equally safe, families and children can choose which regimen they would prefer for future invasive procedures.