POTASSIUM-RICH FRUITS VERSUS POTASSIUM-POOR CITRUS PRODUCTS IN STONE RISK

富含钾的水果与缺乏钾的柑橘类产品存在结石风险

• 批准号: 7377614
• 负责人: CLARITA V ODVINA
• 金额: $ 2.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377614
• 关键词: POTASSIUM; RICH; FRUITS; VERSUS; POOR

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Administration of potassium citrate is now considered an effective treatment for recurrent urolithiasis. It has been shown to decrease stone formation rate in patients with idiopathic hypocitraturic calcium nephrolithiasis by as much as 72% in a placebo-controlled trial. Other studies have demonstrated that potassium citrate therapy can effectively reduce the rate of stone formation in hypocitraturic, hyperuricosuric, as well as in thiazide-unresponsive patients. The effect of potassium citrate is believed to be exerted through its citraturic and alkalinizing actions. Both potassium and citrate are nearly completely absorbed from the gastrointestinal tract. Citrate is nearly completely oxidized in vivo, but absorbed potassium is not metabolized. Thus, a "cation excess" is created, producing an alkali load. The alkali load enhances urinary citrate excretion by reducing renal tubular reabsorption of citrate. A small fraction of the absorbed citrate escapes oxidation in vivo and is excreted in the urine, contributing to the citraturic action of potassium citrate. The object of this study is to compare the urinary alkalinizing and citraturic effects of potassium-rich citrus fruit product (orange juice) with those of potassium-poor product (lemonade) under controlled metabolic conditions in both normal subjects and stone former.s

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。服用柠檬酸钾现在被认为是治疗复发性尿路结石的有效方法。在一项安慰剂对照试验中，它已被证明能降低特发性低柠檬酸钙肾结石患者的结石形成率高达72%。其他研究表明，柠檬酸钾疗法可以有效地降低低柠檬酸、高尿酸尿症患者以及噻嗪无反应患者的结石形成率。柠檬酸钾的作用被认为是通过其柠檬酸和碱化作用发挥的。钾和柠檬酸盐都几乎完全从胃肠道吸收。柠檬酸盐在体内几乎完全被氧化，但吸收的钾不被代谢。因此，产生了“阳离子过剩”，产生了碱负荷。碱负荷通过减少肾小管对柠檬酸的重吸收而增加尿中柠檬酸的排泄。一小部分吸收的柠檬酸逃脱体内的氧化，并在尿液中排泄，有助于柠檬酸钾的柠檬酸尿酸作用。本研究的目的是在受控的代谢条件下，比较富钾柑橘类水果制品(橙汁)和贫钾柑橘类水果制品(柠檬水)对正常人和结石患者尿碱性和柠檬酸的影响。