STUDY TO DETERMINE THE SITE OF INTESTINAL CYSTEAMINE ABSORPTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。测定半胱胺直接给药于胃、小肠或结肠时对白细胞、血液半胱胺和胃泌素水平的影响。了解高胃泌素血症和胃酸分泌过多是否因半胱胺输送部位不同而不同。决定开发一种缓释半胱胺递送系统是否有利，或者简单地将药物递送到不同的肠道部位是否有显著的优势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine the effect of cysteamine on leukocyte cystine, blood cysteamine and gastrin levels when administered directly into the stomach, small intestine or colon. Learn if hypergastrinemia and gastric acid-hypersecretion differ based on the site of cysteamine delivery. Decide whether it might be advantageous to develop a slow-release cysteamine delivery system or whether there would be a significant advantage to simply delivering the drug to a different intestinal site.