NUTRITION, INFECTION AND HEPATIC CARBOHYDRATE METABOLISM

营养、感染和肝脏碳水化合物代谢

• 批准号: 6177153
• 负责人: OWEN P MCGUINNESS
• 金额: $ 25.65万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6177153
• 关键词: blood flow measurement; carbohydrate metabolism; dietary aminoacid; dietary lipid; dogs; fructose; glucagon; glucose clamp technique; glucose metabolism; hyperglucagonemia; infection; liver metabolism; nitric oxide; nutrition related tag

DESCRIPTION: The overall purpose of this research project is to understand why individuals with infections receiving nutritional support develop hyperglycemia, and to determine what can be done to prevent this from occurring. The investigator uses a chronically catheterized conscious dog model, receiving continuous nutritional support. Infection is induced by implantation of a fibrinogen clot into the peritoneal cavity. There are three goals to this proposal: (1) to determine the impact of infection on hepatic glucose uptake and the influence of the route of nutrient delivery on this metabolism. (2) To determine the mechanism for the hyperglucagonemia and the role that excess glucagon and nitric oxide play in the metabolic response to nutrient support during infection. (3) To examine the influence of non glucose nutrients which may either exacerbate or correct the impairment in hepatic glucose disposal.

描述：本研究项目的总体目的是了解 为什么接受营养支持的感染者会 高血糖症，并确定可以采取哪些措施来预防这种情况 正在发生。 研究者使用一只长期插管清醒的狗 模型，接受持续的营养支持。 感染是由 将纤维蛋白原凝块植入腹膜腔。 有 该建议的三个目标：（1）确定感染对 肝脏葡萄糖摄取及营养输送途径的影响 对新陈代谢的影响。 (2)为了确定 高胰高血糖素血症以及过量胰高血糖素和一氧化氮在 在感染期间对营养支持的代谢反应。 (3)审查 非葡萄糖营养素的影响，可能会加剧或 纠正肝脏葡萄糖代谢障碍。