K23: GENDER & ORTHOSTATIC INTOLERANCE: MECHANISMS AND THERAPY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目的主要目的是确定直立耐受的性别差异的潜在机制，包括神经体液对心血管控制过程的影响和决定中央血容量直立分布的身体特征（主要心脏大小和功能）。将检查年轻女性的月经周期变异性，以及患有体位性心动过速综合征（POTS，患者由于难以忍受的轻微头痛、虚弱和近晕厥而无法站立或长时间保持直立）的男性、女性和女性之间的差异。最后，将研究“优化”运动训练作为POTS患者的特异性治疗方法，并与标准药物治疗方法进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this project is to determine the mechanisms underlying gender differences in orthostatic tolerance including neurohumoral influences on cardiovascular control processes and physical characteristics (primary cardiac size and function) that determine orthostatic distribution of central blood volume. Menstrual cycle variability in young women, and differences among men, women, and women with Postural Orthostatic Tachycardia Syndrome (POTS, in which patients are unable to stand or remain upright for prolonger periods of time due to intolerable light headedness, weakness, and near-syncope)will be examined. Finally, "optimized" exercise training will be studied as a specific therapy for patients with POTS and compared with standard pharmacologic therapies.