K23: GENDER AMP; ORTHOSTATIC INTOLERANCE: MECHANISMS AND THERAPY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 该项目的主要目的是确定立位耐力的性别差异的机制，包括神经体液对心血管控制过程和身体特征（主要心脏大小和功能）的影响，这些影响决定了中心血容量的立位分布。 将检查年轻女性的月经周期变异性，以及男性、女性和患有体位性直立性心动过速综合征（POTS，患者由于无法忍受的轻度头晕、虚弱和近晕厥而无法长时间站立或保持直立）的女性之间的差异。 最后，“优化的”运动训练将作为POTS患者的特异性治疗进行研究，并与标准药物治疗进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this project is to determine the mechanisms underlying gender differences in orthostatic tolerance including neurohumoral influences on cardiovascular control processes and physical characteristics (primary cardiac size and function) that determine orthostatic distribution of central blood volume. Menstrual cycle variability in young women, and differences among men, women, and women with Postural Orthostatic Tachycardia Syndrome (POTS, in which patients are unable to stand or remain upright for prolonged periods of time due to intolerable light headedness, weakness, and near-syncope)will be examined. Finally, "optimized" exercise training will be studied as a specific therapy for patients with POTS and compared with standard pharmacologic therapies.