K23: GENDER AMP; ORTHOSTATIC INTOLERANCE: MECHANISMS AND THERAPY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的主要目标是确定立位耐力性别差异的机制，包括神经体液对心血管控制过程和决定中心血容量立位分布的物理特征(心脏大小和功能)的影响。将检查年轻女性的月经周期变异性，以及男性、女性和体位性心动过速综合征(POTS)患者之间的差异，POTS患者由于无法忍受的轻度头痛、虚弱和近晕厥而无法长时间站立或保持直立。最后，“优化的”运动训练将作为POTS患者的一种特定疗法进行研究，并与标准的药物疗法进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this project is to determine the mechanisms underlying gender differences in orthostatic tolerance including neurohumoral influences on cardiovascular control processes and physical characteristics (primary cardiac size and function) that determine orthostatic distribution of central blood volume. Menstrual cycle variability in young women, and differences among men, women, and women with Postural Orthostatic Tachycardia Syndrome (POTS, in which patients are unable to stand or remain upright for prolonged periods of time due to intolerable light headedness, weakness, and near-syncope)will be examined. Finally, "optimized" exercise training will be studied as a specific therapy for patients with POTS and compared with standard pharmacologic therapies.