ROLE OF BONE IN ABSORPTIVE HYPERCALCIURIA

骨在吸收性高钙尿症中的作用

• 批准号: 7377599
• 负责人: HOWARD J HELLER
• 金额: $ 1.68万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377599
• 关键词: ROLE; BONE; ABSORPTIVE; HYPERCALCIURIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Absorptive hypercalciuria (AH), characterized by excess intestinal calcium absorption, is a major cause of nephrolithiasis. Although bone loss is unexpected in this condition, it is common particularly in severe disease based on several bone density studies. Small studies have investigated iliac crest bone biopsies by histomorphometric analysis in hypercalciuric stone-formers, but the subjects were not fully characterized. Therefore, it is still unclear whether bone loss in severe AH is due to low formation or excess bone resorption and whether the bone contributes to the hypercalciuric state. The goal of this project is to better elucidate the pathophysiologic mechanisms for bone loss and hypercalciuria in severe AH to allow formulation of more rational treatment modalities. The hypotheses are 1) the main cause of bone loss in subjects with severe AH is reduced bone formation in the setting of normal or slightly increased bone resorption, and 2) hypercalciuria in severe AH is primarily caused by excessive intestinal calcium absorption, but the bone may contribute in some subjects.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。吸收性高钙尿症（AH），以肠道钙吸收过多为特征，是肾结石的主要原因。尽管在这种情况下骨质流失是意料之外的，但根据几项骨密度研究，它在严重疾病中是很常见的。小型研究通过组织形态学分析调查了高钙尿酸结石患者的髂嵴骨活检，但受试者没有完全表征。因此，目前尚不清楚严重AH的骨质流失是由于骨形成不足还是骨吸收过多，以及骨是否参与了高钙血症状态。本项目的目的是为了更好地阐明严重AH患者骨质流失和高钙尿的病理生理机制，从而制定更合理的治疗方案。假设是：1)严重AH患者骨质流失的主要原因是在骨吸收正常或略有增加的情况下骨形成减少；2)严重AH患者高钙尿主要是由于肠道钙吸收过多引起的，但部分患者的骨骼也可能起作用。