DOES MELATONIN REDUCE URINARY CALCIUM IN HYPERCALCIURIC STONE-FORMERS?

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本初步研究的具体目的是：1)确定褪黑激素是否会降低高钙尿酸结石患者在指导和/或持续代谢饮食中的尿钙，以及这种效果是否会随着停药而消失。2)探讨褪黑素对高钙结石形成者低钙效应的可能机制（改变肠道钙吸收、骨吸收、骨形成和/或肾钙重吸收），这些结石形成者进食指示和/或恒定代谢饮食。3)确定褪黑素在治疗期间和停药后对肾结石危险因素的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this pilot study are: 1) to determine if melatonin lowers urinary calcium in hypercalciuric stone-formers consuming instructed and/or constant metabolic diet and if this effect is lost with discontinuation. 2) to explore the possible mechanism (change in intestinal calcium absorption, bone resorption, bone formation, and/or renal calcium reabsorption) of hypocalciuric effect of a melatonin in hypercalciuric stone-formers consuming instructed and/or constant metabolic diet. 3) to determine the effect of melatonin on kidney stone risk factors during treatment and after discontinuation of melatonin.