DOES MELATONIN REDUCE URINARY CALCIUM IN HYPERCALCIURIC STONE-FORMERS?

褪黑激素是否会降低高钙尿结石患者的尿钙含量？

• 批准号: 7377633
• 负责人: HOWARD J HELLER
• 金额: $ 0.47万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377633
• 关键词: DOES; MELATONIN; REDUCE; URINARY; CALCIUM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this pilot study are: 1) to determine if melatonin lowers urinary calcium in hypercalciuric stone-formers consuming instructed and/or constant metabolic diet and if this effect is lost with discontinuation. 2) to explore the possible mechanism (change in intestinal calcium absorption, bone resorption, bone formation, and/or renal calcium reabsorption) of hypocalciuric effect of a melatonin in hypercalciuric stone-formers consuming instructed and/or constant metabolic diet. 3) to determine the effect of melatonin on kidney stone risk factors during treatment and after discontinuation of melatonin.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。这项试点研究的具体目的是：1) 确定褪黑素是否会降低高钙尿结石患者在接受指导和/或持续代谢饮食的情况下的尿钙水平，以及这种作用是否会随着停药而消失。 2) 探索褪黑素对高尿钙结石患者服用指导性和/或持续代谢饮食的低尿钙作用的可能机制（肠钙吸收、骨吸收、骨形成和/或肾钙重吸收的变化）。 3) 确定褪黑激素在治疗期间和停用褪黑激素后对肾结石危险因素的影响。