TREATMENT OF HYPERLIPIDEMIA OF HIV+ SUBJECTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在接受蛋白酶抑制剂联合治疗的HIV+患者中，高脂血症是一种常见的代谢异常，这种异常使这些患者发生急性胰腺炎和动脉粥样硬化的风险增加。鱼油含有高浓度的长链n-3多不饱和脂肪酸，具有较强的降甘油三酯作用。谷甾醇，一种植物固醇，已被证明是一种安全有效的方法，每天2-3克的剂量可以降低6-15%的低密度脂蛋白胆固醇。本研究的目的是确定鱼油和谷甾醇单独或联合治疗在蛋白酶抑制剂联合治疗的HIV+患者中发生的高脂血症的有效性和安全性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hyperlipidemia is a common metabolic abnormality in HIV+ patients on protease inhibitor combination therapy and this abnormality places these patients at increased risk for developing acute pancreatitis and also possibly for atherosclerosis. Fish oil, which contains high concentration of long-chain n-3 polyunsaturated fatty acids, has potent hypotriglyceridemic effect. Sitostanol, a plant sterol, has been shown to be a safe and efficacious way to reduce LDL cholesterol by 6-15% at doses of 2-3 grams per day. The aim of this study is to determine the efficacy and safety of fish oil and sitostanol, alone and in combination in treating the hyperlipidemia which occurs in HIV+ patients on protease inhibitor combination therapy.