CARDIOPULMONARY EXERCISE TESTING IN PULMONARY HYPERTENSION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究将有助于确定CPET和其他参数(S)是否可以帮助医生对肺动脉高压患者做出关键的临床决策。从我们的大型PAH转诊诊所，我们将按照世界卫生组织的定义，对72名患有PAH的人类受试者进行CPET。我们将研究PAH的肺筋膜病如何影响运动有氧能力和呼吸效率，以及这些反映心肺筋膜功能的重要指标如何与传统的疾病严重程度和治疗反应量化测量中使用的临床指标相关。因此，重要的治疗决定可以基于对运动的循环和呼吸反应的客观测量。这项建议将使PI能够参与一个结构化的、分级的职业发展计划，从而获得以患者为导向的心血管研究职业所需的技能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will help determine if CPET and other parameter(s) can help doctors make critical clinical decisions in patients with pulmonary arterial hypertension. From our large PAH referral clinic, we will perform CPET in 72 human subjects with PAH, as defined by the World Health Organization. We will examine how the pulmonary fasculopathy of PAH affects exercise aerobic capacity and ventilatory efficiency, and how these important reflections of cardiac and pulmonary fascular function relate to clinical indices used in the conventional quantitative measures of disease severity and response to therapy. Therefore important therapeutic decisions can be based on objective measures of the circulatory and ventilatory responses to exercise. This proposal will enable the PI to participate in a structured, graded career development program leading to the acquisition of skills needed for a career in patient-oriented cardiovascular research.