CARDIOPULMONARY EXERCISE TESTING IN PULMONARY HYPERTENSION

肺动脉高压的心肺运动测试

• 批准号: 7606176
• 负责人: RONALD J. OUDIZ
• 金额: $ 1.04万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606176
• 关键词: Aerobic Exercise; Affect; Cardiac; Cardiopulmonary; Cardiovascular system; Clinic; Clinical; Clostridium perfringens epsilon toxin; Computer Retrieval of Information on Scientific Projects Database; Exercise; Exercise stress test; Funding; Grant; Institution; Lung; Measures; Patients; Program Development; Pulmonary Hypertension; Research; Research Personnel; Resources; Severity of illness; Source; Structure; Therapeutic; United States National Institutes of Health; World Health Organization; base; career; human subject; indexing; patient oriented; pulmonary arterial hypertension; response; skill acquisition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will help determine if CPET and other parameter(s) can help doctors make critical clinical decisions in patients with pulmonary arterial hypertension. From our large PAH referral clinic, we will perform CPET in 72 human subjects with PAH, as defined by the World Health Organization. We will examine how the pulmonary fasculopathy of PAH affects exercise aerobic capacity and ventilatory efficiency, and how these important reflections of cardiac and pulmonary fascular function relate to clinical indices used in the conventional quantitative measures of disease severity and response to therapy. Therefore important therapeutic decisions can be based on objective measures of the circulatory and ventilatory responses to exercise. This proposal will enable the PI to participate in a structured, graded career development program leading to the acquisition of skills needed for a career in patient-oriented cardiovascular research.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究将有助于确定CPET和其他参数是否可以帮助医生对肺动脉高压患者做出关键的临床决策。在我们的大型PAH转诊诊所，我们将对72例PAH受试者（根据世界卫生组织的定义）进行CPET。我们将研究PAH的肺肌束病变如何影响运动有氧能力和呼吸效率，以及这些重要的心肺肌束功能反映如何与疾病严重程度和治疗反应的常规定量测量中使用的临床指标相关。因此，重要的治疗决策可以基于对运动的循环和排泄反应的客观测量。该提案将使PI能够参与结构化的分级职业发展计划，从而获得以患者为导向的心血管研究职业所需的技能。