EXERCISE REHABILITATION IN PULMONARY ARTERIAL HYPERTENSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定肺动脉高压（PAH）患者运动康复计划的安全性和有效性。 本研究将招募16例患者参与拟定试验。所有患者将在基线时进行血液检查，并在基线时进行6分钟步行测试和CPET（增加工作负荷，达到最大值），以检查肺动脉高压如何影响其响应运动向肌肉输送氧气的能力。所有患者还将完成一份调查问卷，以评估其生活质量（SF-36调查问卷），并将进行第二次CPET（恒定工作负荷至疲劳）。患者将在J-4的医生和物理治疗师的监督下接受为期6周的正式运动训练，该机构具有完善的强化短期运动训练方案。6周后，将重复CPET，问卷调查和血液检查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine the safety and efficacy of an exercise rehabilitation program in patients with pulmonary arterial hypertension (PAH). This study will recruit 16 patients for participation in the proposed trial. All patients will have a blood test at baseline and undergo 6-minute walk testing and CPET (increasing workload, to maximum) at baseline in order to examine how their pulmonary hypertension affects their ability to deliver oxygen to their muscles in response to exercise. All patients will also complete a questionnaire to rate their quality of life (SF-36 questionnaire), and will have a second CPET (constant workload, to fatigue). Patients will undergo formal exercise training for 6 weeks under the supervision of a physician and physical therapist in J-4, a facility that has a well-established protocol for intensive, short duration exercise training. AFter 6 weeks, the CPEts, questionnaire, and blood tests will be repeated.