课题基金 / 基金详情

EFFECT OF A PROTEASE INHIBITOR-CONTAINING OR A NON-PROTEASE INHIBITOR-CONTAINING

EFFECT OF A PROTEASE INHIBITOR-CONTAINING OR A NON-PROTEASE INHIBITOR-CONTAINING
含有蛋白酶抑制剂或不含蛋白酶抑制剂的效果
批准号:
7379090
负责人:
MICHAEL P DUBE
金额:
$6.36万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-12-01 至 2006-11-30

项目摘要

项目成果

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中文摘要
翻译
这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金,因此可能会出现在其他CRISE条目中。列出的机构是针对中心的,而不一定是针对调查员的机构。这项前瞻性研究的目的是确定在HIV感染者中,基于非蛋白酶抑制剂的联合抗逆转录病毒治疗是否比基于蛋白酶抑制剂(PI)的方案导致较少的内皮功能障碍。在基线评估和随机分为包含或不包含蛋白酶抑制剂的方案之后,将重复评估,受试者将被切换到包含蛋白酶抑制剂或不含酶抑制剂的方案。评估包括DEXA扫描、葡萄糖钳研究和血液测试,将在24周内重复进行。预计将有24个科目报名。在这项为期六个月的研究中,受试者将进行12次访问。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this prospective study is to determine whether non-protease inhibitor-based combination antiretroviral therapy results in less endothelial dysfunction than a protease inhibitor (PI)-based regimen in HIV-infected subjects. Following baseline evaluations and randomization to either a regimen with or without a protease inhibitor containing regimen, evaluations will be repeated and subjects will be switched to protease inhibitors or non-protease inhibitor containing regimens. Evaluations including a DEXA scan, glucose clamp studies, and blood tests will be repeated at twenty-four weeks. Twenty-four subjects are anticipated to enroll. Subjects will have 12 visits in this six month study.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CROSS-SECTIONAL AND LONGITUDINAL STUDY OF ENDOTHELIAL FUNCTION BY BRACHIAL FLOW-
PLAN FOR OBTAINING INFORMED CONSENT TO USE STORED HUMAN BIOLOGICAL MATERIALS
A PHASE II/III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF URIDINE
EFFECT OF HIV-1 PROTEASE INHIBITORS ON ENDOTHELIAL FUNCTION AND GLUCOSE
国内基金
海外基金
抑素蛋白(prohibitin)1调控蛋白酶激活受体(protease-activated receptor)1内化转运及降解的功能和机制
三角帆蚌丝氨酸蛋白酶(serine protease)基因的克隆、表达调控与功能研究
  • 批准号:
    31040083
  • 项目类别:
    专项基金项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2010
  • 负责人:
    肖调义
  • 依托单位: