EFFECT OF A PROTEASE INHIBITOR-CONTAINING OR A NON-PROTEASE INHIBITOR-CONTAINING

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项前瞻性研究的目的是确定在HIV感染者中，基于非蛋白酶抑制剂的联合抗逆转录病毒治疗是否比基于蛋白酶抑制剂(PI)的方案导致较少的内皮功能障碍。在基线评估和随机分为包含或不包含蛋白酶抑制剂的方案之后，将重复评估，受试者将被切换到包含蛋白酶抑制剂或不含酶抑制剂的方案。评估包括DEXA扫描、葡萄糖钳研究和血液测试，将在24周内重复进行。预计将有24个科目报名。在这项为期六个月的研究中，受试者将进行12次访问。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this prospective study is to determine whether non-protease inhibitor-based combination antiretroviral therapy results in less endothelial dysfunction than a protease inhibitor (PI)-based regimen in HIV-infected subjects. Following baseline evaluations and randomization to either a regimen with or without a protease inhibitor containing regimen, evaluations will be repeated and subjects will be switched to protease inhibitors or non-protease inhibitor containing regimens. Evaluations including a DEXA scan, glucose clamp studies, and blood tests will be repeated at twenty-four weeks. Twenty-four subjects are anticipated to enroll. Subjects will have 12 visits in this six month study.