PILOT STUDY TO ESTABLISH THE USE OF BRACHIAL ULTRASOUND TO MEASURE VASCULAR R

建立使用肱动脉超声测量血管 R 的试点研究

• 批准号: 7606465
• 负责人: MICHAEL P DUBE
• 金额: $ 0.33万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606465
• 关键词: Adult; Atherosclerosis; Blood; Blood Vessels; Catheters; Collection; Communicable Diseases; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Future; Grant; Human; Human Resources; Image; Individual; Institution; Intravenous; Invasive; Laboratories; Measurement; Measures; Performance; Pilot Projects; Placement; Population; Quality Control; Reading; Research; Research Personnel; Resources; Risk; Source; Stimulus; Techniques; Testing; Time; Ultrasonography; United States National Institutes of Health; Universities; Wisconsin; base; blood flow measurement; brachial artery; cohort; experience; in vivo; interest; programs; response; skills; success; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective is to establish local expertise in brachial artery ultrasound assessment of vascular function and to develop local normative data in adult populations. Recent interest in the measurement of vascular function in vivo in humans, in particular endothelial responses, has resulted in a proliferation of techniques for such measurements. Some of these techniques are invasive, requiring the placement of an indwelling intra-arterial and intravenous catheters. These techniques are therefore unsuitable for use in large populations, and carry increased procedural risk to study personnel when subjects with blood-borne infectious diseases are involve. An alternative, noninvasive technique using brachial artery ultrasound to measure the vessel response to stimuli is available. Currently this brachial ultrasound technique is available locally only on a limited basis. The PI Dr. Dub'e is PI of the NHLBI grant providing funds for this pilot project, which will then begin using brachial ultrasound as a substitute for the currently-applied invasive femoral blood flow measurements after the ultrasound technique is established. We plan to establish expertise in the performance of the technique, as well as collect a local set of normative data. As with other ultrasound measurements, the success of these measurements is highly operator-dependent. Therefore, in order to assess and minimize variability due to the technical performance of the technique, we need to perform the technique on a collection of ambulatory volunteers and assess intra-individual variability over time. Adequate technique will be verified through quality control assessments of variability in the data collected from an initial cohort of normal subjects as well as re-reads of the measurements by a laboratory with extensive experience in performing this test (University of Wisconsin Atherosclerosis Imaging Program www.cvrc.wisc.edu/airp/, Dr. James Stein, Director). During the establishment of th skills needed for the performance of these subdues, a set of normative data will be collected to serve both as quality controls and also as normal controls for comparison to future studies.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 主要目标是建立肱动脉超声评估血管功能的当地专业知识，并开发成年人群的当地规范数据。 最近对测量人类体内血管功能，特别是内皮反应的兴趣，导致了此类测量技术的激增。其中一些技术是侵入性的，需要放置留置动脉内和静脉内导管。 因此，这些技术不适合在大量人群中使用，并且当涉及患有血源性传染病的受试者时，会给研究人员带来更大的程序风险。 另一种非侵入性技术是使用肱动脉超声来测量血管对刺激的反应。 目前，这种肱骨超声技术只能在有限的基础上局部使用。 PI Dr. Dub'e 是 NHLBI 赠款的 PI，该项目为该试点项目提供资金，在超声波技术建立后，该项目将开始使用肱骨超声作为目前应用的有创股骨血流测量的替代品。 我们计划建立该技术性能的专业知识，并收集一组本地规范数据。 与其他超声测量一样，这些测量的成功与否很大程度上取决于操作员。 因此，为了评估和最小化由于该技术的技术性能而导致的变异性，我们需要对一组流动志愿者执行该技术并评估个体内随时间的变异性。 将通过对从正常受试者的初始队列中收集的数据的变异性进行质量控制评估以及由在执行该测试方面具有丰富经验的实验室重新读取测量值来验证技术是否充分（威斯康星大学动脉粥样硬化成像项目 www.cvrc.wisc.edu/airp/，主任 James Stein 博士）。 在建立执行这些抑制所需的技能期间，将收集一组规范数据，既作为质量控制，又作为与未来研究进行比较的正常控制。