PILOT STUDY TO ESTABLISH THE USE OF BRACHIAL ULTRASOUND TO MEASURE VASCULAR R

建立使用肱动脉超声测量血管 R 的试点研究

• 批准号: 7606465
• 负责人: MICHAEL P DUBE
• 金额: $ 0.33万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606465
• 关键词: Adult; Atherosclerosis; Blood; Blood Vessels; Catheters; Collection; Communicable Diseases; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Future; Grant; Human; Human Resources; Image; Individual; Institution; Intravenous; Invasive; Laboratories; Measurement; Measures; Performance; Pilot Projects; Placement; Population; Quality Control; Reading; Research; Research Personnel; Resources; Risk; Source; Stimulus; Techniques; Testing; Time; Ultrasonography; United States National Institutes of Health; Universities; Wisconsin; base; blood flow measurement; brachial artery; cohort; experience; in vivo; interest; programs; response; skills; success; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective is to establish local expertise in brachial artery ultrasound assessment of vascular function and to develop local normative data in adult populations. Recent interest in the measurement of vascular function in vivo in humans, in particular endothelial responses, has resulted in a proliferation of techniques for such measurements. Some of these techniques are invasive, requiring the placement of an indwelling intra-arterial and intravenous catheters. These techniques are therefore unsuitable for use in large populations, and carry increased procedural risk to study personnel when subjects with blood-borne infectious diseases are involve. An alternative, noninvasive technique using brachial artery ultrasound to measure the vessel response to stimuli is available. Currently this brachial ultrasound technique is available locally only on a limited basis. The PI Dr. Dub'e is PI of the NHLBI grant providing funds for this pilot project, which will then begin using brachial ultrasound as a substitute for the currently-applied invasive femoral blood flow measurements after the ultrasound technique is established. We plan to establish expertise in the performance of the technique, as well as collect a local set of normative data. As with other ultrasound measurements, the success of these measurements is highly operator-dependent. Therefore, in order to assess and minimize variability due to the technical performance of the technique, we need to perform the technique on a collection of ambulatory volunteers and assess intra-individual variability over time. Adequate technique will be verified through quality control assessments of variability in the data collected from an initial cohort of normal subjects as well as re-reads of the measurements by a laboratory with extensive experience in performing this test (University of Wisconsin Atherosclerosis Imaging Program www.cvrc.wisc.edu/airp/, Dr. James Stein, Director). During the establishment of th skills needed for the performance of these subdues, a set of normative data will be collected to serve both as quality controls and also as normal controls for comparison to future studies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 主要目的是在血管功能的肱动脉超声评估中建立本地专业知识，并在成年人群中开发局部规范数据。 最近，人们对人类体内血管功能的测量，特别是内皮反应的兴趣，导致了此类测量的技术的扩散。其中一些技术是侵入性的，需要放置留置动脉内和静脉内导管。 因此，这些技术不适合在大量人群中使用，并且在涉及血液传染性疾病的受试者时，研究人员的程序风险增加。 使用臂动脉超声来测量血管对刺激的反应的替代性无创技术。 目前，这种臂超声技术仅在有限的基础上在本地提供。 PI Dr.Dub'e是NHLBI拨款的PI，为该试点项目提供了资金，然后在建立超声技术后，该项目将开始使用Brachial Ultrasound作为当前应用的入侵性股血流量测量结果的替代品。 我们计划在该技术的性能方面建立专业知识，并收集一组本地的规范数据。 与其他超声测量一样，这些测量值的成功是高度依赖性的。 因此，为了评估和最大程度地减少由于技术的技术性能而导致的可变性，我们需要在集合的门诊志愿者中执行该技术，并评估随着时间的推移的个体内变异性。 将通过从正常受试者的初始组合中收集的数据中的可变性评估以及通过具有丰富经验进行此测试经验的实验室重新阅读测量的质量控制评估（威斯康星大学动脉粥样硬化图像www.cvrc.cvrc.wisc.wisc.edu/airp/，詹姆斯·史蒂芬博士）。 在建立这些典范所需的TH技能期间，将收集一组规范性数据，以作为质量控制，也可以作为正常控制，以与未来的研究进行比较。