PILOT STUDY TO ESTABLISH THE USE OF BRACHIAL ULTRASOUND TO MEASURE VASCULAR R

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 其主要目标是在臂动脉超声评估血管功能方面建立当地的专业知识，并在成人人群中发展当地的标准化数据。 最近对人体体内血管功能的测量，特别是血管内皮细胞反应的兴趣，导致了这种测量技术的激增。其中一些技术是侵入性的，需要放置留置的动脉和静脉导管。因此，这些技术不适合在大量人群中使用，当涉及血液传播传染病的受试者时，会增加研究人员的程序风险。 另一种非侵入性技术，使用臂动脉超声测量血管对刺激的反应是可行的。目前，这种臂部超声技术仅在有限的基础上在当地可用。The Pi Dr.Dub‘e是NHLBI拨款的PI，为该试验项目提供资金，该试验项目将在超声技术建立后开始使用臂部超声作为目前应用的有创股动脉血流测量的替代品。 我们计划在这项技术的性能方面建立专门知识，并收集一组当地的规范数据。与其他超声测量一样，这些测量的成功与否高度依赖于操作员。因此，为了评估和最小化该技术的技术性能带来的变异性，我们需要对一组门诊志愿者进行该技术，并评估随时间推移的个体内变异性。适当的技术将通过对从正常受试者的初始队列中收集的数据的可变性进行质量控制评估，以及由在执行这项测试方面具有丰富经验的实验室重新读取测量数据来验证(威斯康星大学动脉粥样硬化成像计划www.cvrc.ise c.edu/AIRP/，James Stein博士，主任)。 在建立履行这些任务所需技能的过程中，将收集一组规范数据，作为质量控制和正常控制，以便与未来的研究进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective is to establish local expertise in brachial artery ultrasound assessment of vascular function and to develop local normative data in adult populations. Recent interest in the measurement of vascular function in vivo in humans, in particular endothelial responses, has resulted in a proliferation of techniques for such measurements. Some of these techniques are invasive, requiring the placement of an indwelling intra-arterial and intravenous catheters. These techniques are therefore unsuitable for use in large populations, and carry increased procedural risk to study personnel when subjects with blood-borne infectious diseases are involve. An alternative, noninvasive technique using brachial artery ultrasound to measure the vessel response to stimuli is available. Currently this brachial ultrasound technique is available locally only on a limited basis. The PI Dr. Dub'e is PI of the NHLBI grant providing funds for this pilot project, which will then begin using brachial ultrasound as a substitute for the currently-applied invasive femoral blood flow measurements after the ultrasound technique is established. We plan to establish expertise in the performance of the technique, as well as collect a local set of normative data. As with other ultrasound measurements, the success of these measurements is highly operator-dependent. Therefore, in order to assess and minimize variability due to the technical performance of the technique, we need to perform the technique on a collection of ambulatory volunteers and assess intra-individual variability over time. Adequate technique will be verified through quality control assessments of variability in the data collected from an initial cohort of normal subjects as well as re-reads of the measurements by a laboratory with extensive experience in performing this test (University of Wisconsin Atherosclerosis Imaging Program www.cvrc.wisc.edu/airp/, Dr. James Stein, Director). During the establishment of th skills needed for the performance of these subdues, a set of normative data will be collected to serve both as quality controls and also as normal controls for comparison to future studies.