ANABOLIC THERAPIES FOR MUSCLE DYSFUNCTION IN WOMEN WITH COPD

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。确定重度COPD女性患者的运动耐量是否会通过1）睾酮补充或2）力量训练得到改善。制定更好的方法，帮助患有肺病、支气管炎和肺气肿的妇女康复。该项目是对患有这些疾病的男性进行类似治疗的研究。将探讨两种疗法：1）睾丸激素，已知可以加强肌肉，2）腿部肌肉的力量训练（例如，举重）。前一种疗法正在探索中，因为越来越清楚的是，尽管女性的睾酮水平比男性低得多，但睾酮是女性肌肉生长的重要介质。已发现患有肺部疾病的女性中的睾酮水平较低，我们的目的是将水平提高到健康年轻女性中的水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine whether the exercise tolerance of women with severe COPD will be improved by 1) testosterone supplementation or 2) strength training. To devise better ways to rehabilitate women with lung diseases, bronchitis and emphysema. This project follows on a study of similar therapies in men with these diseases. Two therapies will be explored: 1) testosterone, known to strengthen the muscles, 2) strength training (for example, weight lifting) of the leg muscles. The former therapy is being explored because it is becoming clear that although levels of testosterone are much lower in women than in men, testosterone is an important mediator of muscle growth in women. Testosterone levels have been found to be low in women with lung disease and our intention is to increase levels to those seen in healthy young women.