EFFECT OF MEGESTROL ACETATE AND TESTOSTERONE ON BODY COMPOSITION AND HORMONAL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将确定每天口服800毫克甲地孕酮和每周肌肉注射睾酮12周是否会增加COPD非自愿减肥患者的体重和肌肉质量。它还将确定是否有更高的运动耐量和肌肉力量，血液炎症介质的变化或日常活动水平的变化。男性的睾丸素剂量将高于女性，剂量将进行调整，以达到预期的血液水平：男性，处于年轻男性正常范围的高端；女性，略高于年轻女性正常范围的高端。 这项研究旨在作为一项更大规模的安慰剂对照多中心试验的先导性研究。将不设对照组；每个患者将作为自己的对照组。我们建议治疗12名参与者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will determine whether 12 weeks of taking both 800mg of megestrol acetate daily by mouth combined with testosterone given weekly by intramuscular injection increases body weight and muscle mass in COPD patients with involuntary weight loss. It will also determine whether there are increased exercise tolerance and muscle strength, changes in blood inflammatory mediators or changes in the level of everyday activity. Testosterone doses will be higher for men than for women and doses will be adjusted to achieve desired blood levels: for men, at the high end of the normal range for young men; for women, somewhat above the high end of the normal range for young women. This study is intended as a pilot study for a larger placebo-controlled, multi-center trial. There will be no control group; each patient will serve as their own control. We propose to treat 12 participants.