LONG-TERM OXYGEN TREATMENT TRIAL

长期氧气治疗试验

• 批准号: 8174516
• 负责人: RICHARD CASABURI
• 金额: $ 0.18万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174516
• 关键词: Activities of Daily Living; Anxiety; Area; Blood; Breathing; Cause of Death; Chronic Obstructive Airway Disease; Computer Retrieval of Information on Scientific Projects Database; Coughing; Disease; Flare; Funding; Gases; Goals; Grant; Guidelines; Hour; Impairment; Institution; Lung; Mental Depression; Nutritional status; Oxygen; Oxygen Therapy Care; Patients; Personal Satisfaction; Persons; Quality of life; Questionnaires; Randomized Clinical Trials; Research; Research Personnel; Resources; Rest; Shortness of Breath; Sleep; Source; Structure of parenchyma of lung; Survival Rate; Symptoms; Test Result; United States; United States National Institutes of Health; Walking; airway inflammation; health care service utilization; health related quality of life; improved; respiratory; secondary outcome; treatment trial

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic Obstructive Pulmonary Disease (COPD) is currently as the 4th leading cause of death in the United States, and is expected to rise to #3 worldwide by the year 2020. This disease can cause destruction of lung tissue, inflammation of the airways in the lungs, as well as increased cough, shortness of breath and limitation of daily activities. Because of impairment in gas exchange in the lungs, many persons with COPD require supplementary oxygen supply to maintain adequate blood oxygen levels. Current guidelines recommend prescribing supplementary oxygen for patients with oxygen saturation levels of 88% or less. Such oxygen administration has been shown to be of benefit in improved survival rates, as well as increased ability to perform activities of daily living. The Long-term Oxygen Treatment Trial (LOTT) is a National Institutes of Health sponsored multi-center, randomized clinical trial of continuous (24-hour) supplemental oxygen therapy versus no supplemental oxygen therapy for patients with COPD and a moderately low resting blood oxygen level. The trial primary goal is to determine if continuous supplemental oxygen therapy results in improved survival. High priority secondary outcomes are disease-specific quality of life (St. George s Respiratory Questionnaire) and a more general health-related quality of life (Quality of Well-Being Scale). The study will also look at the rate of COPD flare-ups, degree of shortness of breath, six-minute walk distance, nutritional status and health care utilization. Other areas to be examined include breathing test results, general quality of life, sleep quality, and depression and anxiety symptoms.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 慢性阻塞性肺疾病(COPD)目前是美国第四大死因，预计到2020年将上升到全球第三位。这种疾病可导致肺组织破坏，肺部呼吸道发炎，以及咳嗽加剧、呼吸短促和日常活动受限。 由于肺部气体交换障碍，许多COPD患者需要补充氧气供应以维持足够的血氧水平。目前的指南建议对血氧饱和度水平在88%或更低的患者开补充氧。这样的氧气管理已被证明有利于提高存活率，以及增强进行日常生活活动的能力。 长期氧疗试验(LOTT)是由美国国立卫生研究院赞助的一项多中心随机临床试验，对COPD和中度低静息血氧水平的患者进行持续(24小时)补充氧疗和不补充氧疗的临床试验。 试验的主要目标是确定持续补充氧疗是否能提高存活率。高度优先的次要结果是特定疾病的生活质量(圣乔治S呼吸问卷)和更一般的与健康相关的生活质量(幸福质量量表)。这项研究还将考察COPD的发病率、呼吸急促程度、6分钟步行距离、营养状况和医疗保健利用情况。其他需要检查的领域包括呼吸测试结果、一般生活质量、睡眠质量以及抑郁和焦虑症状。