PERINATAL CORE PROTOCOL FOR HIV INFECTED WOMEN (PACTG P1025, VERSION 20)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。虽然太平洋行动小组的主要任务传统上是进行临床试验，但目前在育龄妇女中艾滋病毒感染的流行病方面，太平洋行动小组招募孕妇参加一项非介入性、分析性的流行病学研究是适当和必要的，以便系统地收集妇女及其婴儿的临床和实验室数据。通过这种方式，《太平洋行动计划》可以实现以下重要目标：评价对怀孕期间感染艾滋病毒的妇女的管理，确定抗逆转录病毒疗法和其他旨在防止垂直传播和/或改善孕产妇健康的干预措施的安全性和有效性。PACTG 367已证明，可以从在PACTG站点接受护理的妇女及其婴儿中前瞻性地收集数据。此外，这些数据可以在持续的基础上进行分析，提供重要的信息，不仅用于临床试验的设计，也用于临床护理的修改。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although the major mission of the PACTG has traditionally been to conduct clinical trials, at this time in the epidemic of HIV-infection in child-bearing women, it is both appropriate and necessary for the PACTG to recruit pregnant women into a non-interventional, analytic, epidemiologic study in order to methodically collect clinical and laboratory data from the women and their infants. In this way, the PACTG can achieve the important aims of evaluating managment of HIV-infected women during pregnancy and determining the safety and effectiveness of ART and other interventions intended to prevent vertical transmission and/or improve maternal health. PACTG 367 has demonstrated that data can be collected prospectively from women and their infants receiving care at PACTG sites. Furthermore, these data can be analyzed on an ongoing basis to provide important information used not only for the design of clinical trials, but also for modification of clinical care.