GLYBURIDE VERSUS INSULIN IN THE MANAGEMENT OF GESTATIONAL DIABETES

格列本脲与胰岛素治疗妊娠期糖尿病的比较

• 批准号: 7376073
• 负责人: LYNNE T SMITH
• 金额: $ 1.04万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376073
• 关键词: GLYBURIDE; VERSUS; INSULIN; MANAGEMENT; GESTATIONAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this study is to assess the efficacy of glyburide compared to insulin in the management of gestational diabetic subjects that did not respond to nutritional therapy in the Obstetrics Department of King Drew Medical Center, Los Angeles, CA. This is a prospective, randomized and open trial. Four hundred pregnant women with gestational diabetes who have failed to achieve adequate blood glucose control on ADA diet will be recruited for the study. The women will be randomly assigned into the two Groups (A=Insulin recipients (200) and B=Glyburide recipients (200)). Eligible subjects from all ethnic groups will be enrolled. All subjects will be followed by blood glucose monitoring throughout pregnancy and adjustments of medication will be made when a

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究的主要目的是评估格列本脲与胰岛素相比在管理营养治疗无效的妊娠期糖尿病受试者中的疗效，这些受试者在King Drew Medical Center（洛杉矶，CA）的产科接受治疗。这是一项前瞻性、随机化和开放性试验。本研究将招募400名患有妊娠期糖尿病的孕妇，这些孕妇在服用ADA饮食后血糖控制不佳。这些妇女将被随机分配到两组（A=胰岛素接受者（200）和B=格列本脲接受者（200））。将入组来自所有种族组的合格受试者。所有受试者将在整个妊娠期间接受血糖监测，并在出现以下情况时调整药物治疗：