PRENATAL METHAMPHETAMINE EXPOSURE AND CHILD DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管甲基苯丙胺在一些地区的使用量非常高，但人们对产前接触甲基苯丙胺对儿童发育的潜在神经毒性影响知之甚少。已经建立了一个社区研究网络，在四个甲基苯丙胺使用盛行的地区(爱荷华州、俄克拉何马州、加利福尼亚州和夏威夷)对产前甲基苯丙胺暴露和儿童结局进行纵向研究。这个由NIDA资助的项目提议进行一项为期三年的纵向发展跟踪研究。我们将在新生儿期、1岁、2岁和3岁时对儿童进行评估。我们将测试与产前接触甲基苯丙胺对儿童结局影响的假设，当包括其他药物使用在内的协变量得到控制时。还将研究有关心理社会风险因素在产前暴露甲基苯丙胺对儿童结局影响的中介作用的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the fact that methamphetamine use is very high in some regions, little is known about the potential neurotoxic effects of prenatal methamphetamine exposure on the development of children. A Community Research Network has been established to conduct a longitudinal study of prenatal methamphetamine exposure and child outcome in four areas (Iowa, Oklahoma, California, and Hawaii) in which methamphetamine use is prevalent. This NIDA funded project proposes to conduct a three-year longitudinal developmental follow-up study. Children will be evaluated in the newborn period and at ages 1,2 and 3. We will test hypotheses related to the effects of prenatal methamphetamine exposure on child outcome when covariates including other drug use are controlled. Hypotheses related to the role of psychosocial risk factors mediating effects of prenatal methamphetamine exposure on child outcome will also be studied.