PRENATAL METHAMPHETAMINE EXPOSURE AND CHILD DEVELOPMENT

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 尽管某些地区甲基苯丙胺的使用率很高，但人们对产前接触甲基苯丙胺对儿童发育的潜在神经毒性影响知之甚少。建立了一个社区研究网络，对甲基苯丙胺使用普遍的四个地区（爱荷华州、俄克拉荷马州、加州和夏威夷）的产前甲基苯丙胺暴露和儿童结局进行纵向研究。该NIDA资助的项目建议进行一项为期三年的纵向发展后续研究。儿童将在新生儿期和1岁、2岁和3岁时接受评估。我们将检验与产前甲基苯丙胺暴露对儿童结局影响相关的假设，当控制包括其他药物使用在内的协变量时。还将研究与心理社会风险因素介导产前甲基苯丙胺暴露对儿童结局影响的作用相关的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the fact that methamphetamine use is very high in some regions, little is known about the potential neurotoxic effects of prenatal methamphetamine exposure on the development of children. A Community Research Network has been established to conduct a longitudinal study of prenatal methamphetamine exposure and child outcome in four areas (Iowa, Oklahoma, California, and Hawaii) in which methamphetamine use is prevalent. This NIDA funded project proposes to conduct a three-year longitudinal developmental follow-up study. Children will be evaluated in the newborn period and at ages 1,2 and 3. We will test hypotheses related to the effects of prenatal methamphetamine exposure on child outcome when covariates including other drug use are controlled. Hypotheses related to the role of psychosocial risk factors mediating effects of prenatal methamphetamine exposure on child outcome will also be studied.