AMNIOTIC FLUID AND INFANT MONITORING FOR PARATHYROID HORMONE-RELATED PROTEIN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：测定妊娠期间羊水中甲状旁腺激素相关蛋白的浓度。最初，胎肺产生甲状旁腺素受体是很普遍的。随着气囊的发育，甲状旁腺素受体的产生受到气囊内层的限制。在妊娠期间，发育中的肺会产生胎儿肺液，然后分泌到羊水中。分泌的胎儿肺液的路径遵循呼出的空气的路径，通过鼻子和口腔进入羊膜腔。我们假设肺通过胎儿肺液为羊水提供甲状旁腺素。此外，我们假设PTHrP在妊娠期间的浓度增加，类似于饱和磷脂酰胆碱和磷脂酰甘油。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine the concentration of parathyroid hormone related protein in amniotic fluid during the course of gestation. The production of PTHrP by the fetal lung is at first widespread. As the air sacs develop the production of PTHrP becomes restricted to the lining of the air sacs. During gestation the developing lungs produce fetal lung fluid which is secreted into the amniotic fluid. The path of the secreted fetal lung fluid follows that of exhaled air, through the nose and mouth into the amniotic cavity. We hypothesize that the lung contributes PTHrP to the amniotic fluid via fetal lung fluid. Further, we hypothesize that the concentrations of PTHrP increase during gestation similar to saturated phosphatidylcholine and phosphatidylglycerol.