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HORMONAL CONTROL OF LUNG DEVELOPMENT--PTHRP BIOLOGY

HORMONAL CONTROL OF LUNG DEVELOPMENT--PTHRP BIOLOGY
肺部发育的激素控制--PTHRP 生物学
批准号：
2029599
负责人：
John Steven Torday
金额：
$22.15万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-08-01 至 1998-03-31
来源：
https://reporter.nih.gov/project-details/2029599
关键词：
RNase protection assay animal tissue cell cell interaction cell differentiation embryo /fetus fibroblast growth factor gel electrophoresis gene expression growth /development hormone regulation /control mechanism in situ hybridization laboratory mouse lipoprotein lipase lung alveolus mesenchyme messenger RNA northern blottings nucleic acid probes organ culture parathyroid hormone related protein protein structure function second messengers statistics /biometry transmission electron microscopy western blottings

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DESCRIPTION: (Adapted from the applicant's abstract) The proposed studies are specifically designed to test the following hypotheses: (1) stretch-initiated transduction in fetal type II cells triggers PTHrP production; (2) PTHrP stimulates fetal lung fibroblast maturation by receptor-dependent mechanisms; (3) PTHrP stimulates production of mesenchymal cytokines and growth factors which promote type II cell maturation. Elaboration of lipoprotein lipase, glucocorticoid receptor, and PTHrP-regulated fibroblast growth factors and cytokines by PTHrP-deficient lung tissue and fibroblasts will be studied at the mRNA and protein levels to determine which functions are affected in this model.
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HORMONAL CONTROL OF LUNG DEVELOPMENT: PTHRP BIOLOGY
AMNIOTIC FLUID AND INFANT MONITORING FOR PARATHYROID HORMONE-RELATED PROTEIN
AMNIOTIC FLUID AND INFANT MONITORING FOR PARATHYROID HORMONE-RELATED PROTEIN
Amniotic Fluid and Infant Monitoring for Parathyroid Hormone-Related Protein
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