HUPERZINE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。石杉碱A是从中药石杉中提取的天然胆碱酯酶抑制剂。有证据表明，与目前使用的胆碱酯酶抑制剂相比，石杉碱A在对症疗效方面可能更有利。此外，石杉碱A具有抗氧化和神经保护特性，这表明它可能有助于治疗阿尔茨海默病（AD）。这种药物目前在美国作为一种营养药品，被一些美国临床医生用于治疗阿尔茨海默病。然而，在中国以外，尚无对其毒性和疗效进行评估的对照临床试验。主要目的是确定200ug石杉碱A治疗可改善AD患者的认知功能。次要目的是：确定400ug剂量石杉碱A治疗是否能改善AD患者的认知功能。确定石杉碱A治疗对AD患者总体临床状况、日常生活活动和行为的影响。评价200ug bid和400ug bid石杉碱A对AD的耐受性。探讨石杉碱A治疗AD患者血胆碱酯酶活性与认知功能的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata. There is eveidence that huperine A may compare favorably in symptomatic efficacy to cholinesterase inhibitors currently in use. In addition, huperzine A has antioxidant and neuroprotective properties that suggest that it may be useful as a disease-modifying treatment for Alzheimer's disease (AD). the drug is currently available as s nutriceutical in this country, and is being used by some U.S. clinicans to treat AD. However, ther have been no controlled clinical trails outside China assessing its toxicity and efficacy. The primary aim is to determine treatment with huperzine A 200ug bid improves cognitive function in patients with AD. Secondary Aims are: To determine whether treatment with huperzine A 400ug bid improves cognitive function in patients with AD. To determine the effect of huperzine A treatment on global clinical status, activities of daily living, and behavior in AD. To evaluate the tolerability of huperzine A treatment at dosages of 200ug bid and 400ug bid in AD. To determine the relationship between blood cholinesterase activity and cognitive function in AD patients treated with huperzine A.