MIRAGE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在幻影III中，研究人员正在将他们的注意力转向越来越多的来自病理学、流行病学和遗传学研究的证据，这些证据表明血管疾病的风险因素也会增加AD的风险。然而，由于大多数流行病学研究缺乏神经影像数据，尚不清楚血管危险因素与阿尔茨海默病之间的明显联系是通过脑缺血损伤、加速原发阿尔茨海默氏神经退变过程或其他过程而起作用。一些血管危险因素在非裔美国人和日裔美国人中比在高加索人中更普遍。研究人员参与了血管功能和其他脑血管健康指标，包括血压和结构脑成像(MRI)，以及这些民族对AD的易感性。为了成功地开展这一项目，将从美国、加拿大和德国的11个中心收集符合NINCDS/ADRDA标准的1000名患者(500名高加索人，300名非裔美国人，200名日裔美国人)的样本，这些患者包括先证者和在世的兄弟姐妹，以及50岁以上的配偶和子女。DNA、血浆Aβ亚型和大脑MRI将在先证者和兄弟姐妹中进行评估。该计划的科学目标是： 1.研究最近发现的阿尔茨海默病风险与磁共振成像(MRI)变量之间的关系，调整APOE基因和其他危险因素。 2.采用高通量基因分型技术、同胞对连锁分析和家系关联方法，研究1000个家系中100个可能影响血管功能的基因的单核苷酸多态性(SNP)与阿尔茨海默病的相关性。 3.比较这些SNP在高加索人、非裔美国人和日裔美国人兄弟姐妹中的相对贡献，以及其他因素，包括血压、高血压治疗、疾病的血浆Abeta和影像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In MIRAGE III, the researchers are turning their attention to the growing body of evidence from pathological, epidemiological and genetic studies that risk factors for vascualar disease also enhance the risk of AD. However, since most epidemiological studies lack neuroimaging data, it is unclear whether the apparent association between vascular risk factors and AD is medicated via ischemic injury to the brain, acceleration of the primary Alzheimer's neurodegenerative process, or some other process. Some vascular risk factors are more prevalent in African American and Japanese American populations than in Caucasians. The researchers involved in vascular function and other indicators of cerebrovascular health including blood pressure and structural brain imaging (MRI), and susceptibility to AD in these ethnic groups. In order to carry out this project successfully, a sample of 1000 patients (500 Caucasians, 300 African Americans, 200 Japanese Americans) who meet NINCDS/ADRDA critera for probable or definite AD from 11 centers in the US, Canada and Germany will be collected from the probands and living siblings, spouses and children over the age of 50 years. DNA, plasma A beta isoforms and MRI of the brain will be evaluated in probands and siblings. The scientific aims of the are: 1. To examine recently discovered associations between the risk of AD and magnetic resonance imaging (MRI) variables, adjusting for APOE genotype and other risk factors. 2. To examine the association between single nucleotide polymorphisms (SNP's) in 100 genes posited to have a role in vascular function and AD in 1000 sibships using high throughput genotyping technology, and sibling pair linkage and family-based association methodologies. 3. To compare the relative contributions of these SNP's and other factors including blood pressure, treatment for hypertension, and plasma Abeta of disease and imaging otucomes in Caucasian, African American and Japanese American Sibships.