ADNI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究将测试是否可以将系列磁成像（MRI）、正电子发射断层扫描（PET）、其他生物标志物以及临床和神经心理学评估结合起来，以测量轻度认知障碍（MCI）和早期阿尔茨海默病（AD）的进展。通过研究MCI和AD患者和健康个体的脑图像变化以及其他评估工具获得的信息将用于确定测量MCI和AD患者治疗效果的最佳方法。 研究将招募约800名年龄在55至90岁之间的参与者：400名MCI患者，200名早期AD患者和200名正常对照。MCI患者和正常对照将随访3年，AD患者将随访2年。每隔6个月，所有参与者将在每次扫描时亲自见到或联系。所有受试者将接受重复扫描，每次扫描时将采集血液和尿液生物标志物。将询问所有患者是否愿意在基线和第1年接受腰椎穿刺，目标是每组中至少20%和多达50%的患者提供CSF样本用于分析和储存，以备将来分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test whether serial magnetic imaging(MRI), positron emission tomography(PET), other biological markers, and clinical and neuropsychological assessment can be combined to measure the progression of mild cognitive impairment(MCI) and early alzheimer's disease(AD). The information obtained by studying changes in the brain images of MCI and AD patients and healthy individuals, as well as other assessement tools, will be used to determine the best methods for measuring treatment effects in patients MCI and AD. Aproximately 800 participants, ranging in age 55 to 90, will be recruited for the study: 400 patients with MCI, 200 with early AD, and 200 normal controls. Patients with MCI and normal controls will be followed for 3 years, and those with AD will be followed for 2 years. At 6-month intervals all participants will be seen in person or contacted at the time of each scan. All participant will undergo repeated scanning and blood and urine biomarkers will be collected at the time of each scan. All patients will be asked if they are willing to undergo lumbar puncture at baseline and year one, with the goal of a minimum of 20% and as many as 50% of each group providing CSF samples for analysis and storage for future analyses.