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Metabolic Phenotyping in Live Models of Obesity and Diabetes

肥胖和糖尿病活体模型的代谢表型分析

基本信息

批准号：
10588794
负责人：
Carol Fuzeti Elias
金额：
$ 74.1万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10588794
关键词：
Accounting Advertising Animal Experiments Animal Model Animals Anxiety Area Basic Science Behavior assessment Behavioral Biological Biomedical Research Blood specimen Cannulations Chronic Circadian Dysregulation Consultations Core Facility Culex (Genus)Data Databases Development Diabetes Mellitus Educational workshop Experimental Designs Fiber Fostering Funding Genetic Germ-Free Glucose Glucose Clamp Goals Grant Health Health Care Costs Health system Homeostasis Hormone secretion Hormones Housing Human Hyperinsulinism Hypothalamic structure Indirect Calorimetry Individual Indwelling Catheter Institution Investments Laboratories Leadership Learning Lipids Liquid substance Medicine Mental Depression Metabolic Metabolic Diseases Metabolism Michigan Modeling Morbidity - disease rate Motor Activity Mus National Institute of Diabetes and Digestive and Kidney Diseases Obesity Operant Conditioning Operative Surgical Procedures Parabiosis Pathogenesis Pattern Phenotype Photometry Physical activity Physiological Physiology Portal vein structure Protocols documentation Reproducibility Research Research Personnel Resources Role Sampling Services Standardization Technology Temperature Testing Tracer Training Training Programs Translational Research Transportation Universities animal care arm base behavior measurement behavioral phenotyping behavioral response blood glucose regulation brain surgery burden of illness comorbidity cost dietary experience feeding glucose tolerance hedonic improved in vivo insulin tolerance member metabolic phenotype mortality mouse genetics mouse model novel novel therapeutic intervention obesity treatment optogenetics outreach response tool

项目摘要

Project Summary / Abstract – Overall Metabolic disorders, including obesity, diabetes and their complications are among the most pressing health issues worldwide accounting for a substantial national burden of morbidity, mortality, and healthcare costs. The University of Michigan Health System (now Michigan Medicine) has strategically invested in both human and physical resources over the past 20 years in a concerted attack on these problems. A key component of this strategy is to foster the development of core laboratories providing expertise and specialized services at accessible cost to researchers throughout the institution. The University of Michigan is also a member of the national consortium established in 2016 by the NIDDK for in-depth phenotyping tests of mouse models of obesity, diabetes, and related metabolic conditions, the Mouse Metabolic Phenotyping Centers (MMPC). The Michigan Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD) will build upon our stablished expertise to provide a unique pallet of standardized, high quality and state-of-the-art in vivo phenotyping services for researchers nationwide with focus on underrepresented PIs and small laboratories or institutions that have not received significant federal research funding. The MPMOD at Michigan will be organized in three distinct cores: The Administrative Core, the Animal Care and Germ-Free Mouse Core, and the Metabolic, Physiological and Behavioral (MPB) Phenotyping Core. The Administrative Core will provide overall scientific and fiscal leadership. It will coordinate phenotyping activities among the individual cores and will foster interaction with phenotyping centers members of the MPMOD Consortium and the Coordinating Unit (CU). The Animal Care and Germ-Free Mouse Core will be responsible for transportation, housing, and veterinary care of animals to be assessed at the MPB Phenotyping Core. The MPB Phenotyping Core will provide a comprehensive battery of in vivo assessments encompassing those provided by the former MMPC, i.e., glucose or lipid homeostasis (glucose tolerance, insulin tolerance, lipid tolerance, hyperinsulinemic- euglycemic clamps with tracers), whole-animal energy homeostasis (indirect calorimetry by CLAMS, SABLE, with dietary and environmental temperature challenges), ultradian hormone secretion (Culex platform for serial biological fluid sampling from free-moving mice without human presence), behavioral measurements (e.g., hedonic and homeostatic feeding responses, and obesity- and/or diabetes-associated changes in learning, anxiety and depression), etc. Additional in vivo services using highly specialized surgical procedures (e.g., chronic portal vein cannulation, parabiosis, and stereotaxic brain surgeries), optogenetic and fiber photometry technologies. Together, the Michigan MPMOD will provide access to a broad range of advanced in vivo phenotyping services, consultation and training taking advantage of our well-stablished metabolic phenotyping facilities and unique expertise on hypothalamic function, mouse genetics and specialized surgeries in experimental animals.

项目摘要/摘要-总体