ACUTE ESTROGEN IN WOMEN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项初步研究是一项非盲试验，旨在确定经皮雌激素对绝经后妇女骨吸收是否有急性作用。具体而言，我们将测定雌二醇水平低于10 pg/ml的65岁以上绝经后妇女接受经皮雌二醇贴剂治疗两周期间骨吸收标志物（C-端肽、N-端肽和游离脱氧吡啶啉）的变化，该贴剂每两周贴敷一次。如果这些女性的骨吸收标志物早期显著减少，我们将计划进行一项更大的安慰剂对照试验，增加时间点，以确认和扩展这些初步数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study is an unblinded trial designed to determine whether there is an acute effect of transdermal estrogen on bone resorption in postmenopausal women. Specifically, we will determine the change in markers of bone resorption (C-telopeptide, N-telopeptide, and free deoxypyridinoline) during two weeks of treatment with a transdermal estradiol patch applied biweekly in postmenopausal women over the age of 65 years with estradiol levels less than 10 pg/ml. If a significant early reduction in resorption markers occurs in these women we will plan a larger placebo-controlled trial with additional time points to confirm and extend these pilot data.