ACUTE ESTROGEN IN WOMEN

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study is an unblinded trial designed to determine whether there is an acute effect of transdermal estrogen on bone resorption in postmenopausal women. Specifically, we will determine the change in markers of bone resorption (C-telopeptide, N-telopeptide, and free deoxypyridinoline) during two weeks of treatment with a transdermal estradiol patch applied biweekly in postmenopausal women over the age of 65 years with estradiol levels less than 10 pg/ml. If a significant early reduction in resorption markers occurs in these women we will plan a larger placebo-controlled trial with additional time points to confirm and extend these pilot data.