Adding Value to the UK Brassica Crop Science Community (AdVAB)

为英国芸苔属作物科学界 (AdVAB) 增加价值

• 批准号: BB/E006892/1
• 负责人: David Pink
• 金额: $ 20.74万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE006892%2F1
• 关键词: Adding; Value; UK; Brassica; Crop

There is a requirement for a comprehensive 'delivery pipeline' to exploit basic plant genetic and genomic knowledge and contribute to trait-led crop R&D leading to tangible outcomes for sustainable agriculture, processors and end-users. The UK is exceptionally well placed to develop this for the oilseed and vegetable brassica crops, which are closely related to the reference species Arabidopsis. The AdVaB consortium represents three leading UK institutions with research and development programmes reflecting comprehensive coverage of the interface between basic plant science and application through the Brassica crop improvement pipeline. The UK Brassica Research Community (UK-BRC) can build on a history of developing and sharing experimental resources, and collaborative research projects. It has identified an active and broad range of R&D through its annual meetings, email list and development of key underpinning resources such as physical maps anchored to the Arabidopsis genome. Strong bilateral and collective interactions exist between research institutes, universities and breeders, with some key components of the delivery pipeline between Brassica genetics research and crop improvement already in place. In the last few years, the Defra Oilseed Rape Genetic Improvement Network (OREGIN), which involves a core project, stakeholder forum and 'satellite' LINK projects, has provided a focus for the interface between end-use stakeholders and the UK R&D community. BBSRC investment has enabled the UK-BRC to develop a high international profile, involving fundamental and strategic research, as well as development of genetic and genomic resources through initiatives (eg IGF), responsive mode and institute funding. Over the past few years, the Multinational Brassica Genome Project (MBGP) has become the focus for development of Brassica genomics and genetics, and arose from an increasing openness of the international Brassica community, catalysed by the IGF project. UK leadership of the MBGP has led to public availability of key experimental resources, and initiation of the Multinational Brassica rapa Sequencing Project. Establishment of the www.brassica.info website provides a focus for collation and exchange of information, and recent publication of a 'Brassica White Paper' has outlined the opportunities for Brassica genetics and genomics in a socio-economic context. The UK has taken the lead in establishing and making available key Brassica genetic and genomic resources in the public domain, benefiting from those developed elsewhere. However, the research and end-user breeding community have identified a number of important gaps in knowledge and technology that currently limit full exploitation through to crop improvement. The proposed 'gap-filling' activities address the need to ensure that the various experimental resources developed in the UK and elsewhere can be navigated readily through explicit access to relevant genome-based information (eg. sequenced genetic markers). They will also provide researchers with ready access to datasets relating to various crop and constituent plant traits that are currently only available in dispersed published or pre-published format. The refinement and development of specific 'reverse genetics' tools will enable UK researchers to maximise the benefits from the establishment of the complete sequence of B. rapa (one of the constituent genomes of oilseed rape). The gaps affect the ability of researchers and breeders to integrate and navigate between genetic maps and associated QTL data, and to understand candidate gene function using reverse genetics tools. This investment in AdVAB will serve to integrate and provide access to disparate sources of existing information, and also maximise the opportunity for the UK-BRC to obtain functional data for candidate genes, so that they can translate research findings more rapidly into practical outcomes, particularly through genetic crop improvement.

需要一个全面的“交付管道”来利用基本的植物遗传和基因组知识，并为性状主导的作物研发做出贡献，从而为可持续农业、加工商和最终用户带来切实的成果。英国在开发油籽和蔬菜芸苔作物方面处于非常有利的地位，这些作物与参考物种拟南芥密切相关。AdVaB联盟代表了英国三家领先的研究机构，他们的研究和开发项目反映了通过芸苔作物改良管道在基础植物科学和应用之间的全面覆盖。英国芸苔研究共同体（UK- brc）可以建立在开发和共享实验资源以及合作研究项目的历史上。它通过年度会议、电子邮件列表和开发关键基础资源（如锚定在拟南芥基因组上的物理地图），确定了一个活跃而广泛的研发领域。研究机构、大学和育种者之间存在着强有力的双边和集体互动，芸苔属植物遗传研究和作物改良之间的一些关键组成部分已经到位。在过去的几年里，Defra油菜遗传改良网络（OREGIN），包括一个核心项目，利益相关者论坛和“卫星”链接项目，为最终用户利益相关者和英国研发社区之间的接口提供了一个焦点。BBSRC的投资使UK-BRC在基础和战略研究以及通过倡议（如IGF）、响应模式和研究所资助的遗传和基因组资源开发方面具有很高的国际知名度。近年来，跨国芸苔基因组计划（MBGP）成为芸苔基因组学和遗传学发展的焦点，是在IGF项目的推动下，国际芸苔界日益开放的产物。英国在MBGP的领导下，已经将关键实验资源向公众开放，并启动了跨国油菜测序项目。www.brassica.info网站的建立为信息的整理和交流提供了一个重点，最近出版的“芸苔白皮书”概述了芸苔遗传和基因组学在社会经济背景下的机会。英国率先在公共领域建立和提供关键的芸苔属遗传和基因组资源，受益于其他地方开发的资源。然而，研究和最终用户育种界已经确定了知识和技术方面的一些重要差距，这些差距目前限制了对作物改良的充分利用。拟议的“填补空白”活动解决了确保在英国和其他地方开发的各种实验资源可以通过明确访问相关的基于基因组的信息(例如；基因标记测序)。它们还将为研究人员提供与各种作物和组成植物性状有关的数据集，这些数据集目前只能以分散出版或预出版的形式获得。特定的“反向遗传学”工具的改进和发展将使英国研究人员能够最大限度地从建立rapa（油菜的组成基因组之一）的完整序列中获益。这些差距影响了研究人员和育种者整合和导航遗传图谱和相关QTL数据的能力，以及使用反向遗传学工具了解候选基因功能的能力。对AdVAB的投资将有助于整合和提供对不同来源的现有信息的访问，并最大限度地提高UK-BRC获得候选基因功能数据的机会，这样他们就可以更快地将研究成果转化为实际成果，特别是通过基因作物改良。