METABOLIC CONSEQUENCES OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) IN HIV

高活性抗逆转录病毒治疗 (HAART) 对 HIV 的代谢影响

• 批准号: 7376248
• 负责人: DAVID M MUSCHATT
• 金额: $ 3.22万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376248
• 关键词: METABOLIC; CONSEQUENCES; HIGHLY; ACTIVE; ANTIRETROVIRAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an urgent need for well-designed, prospective studies to elucidate the incidence, time of onset, pathophysiology, predictors, and clinical significance of metabolic complications associated with HIV infection and/or its treatment. Therefore, the primary objective of this protocol is to compare changes in total cholesterol, triglycerides, waist circumference, and waist-to-hip ratio from baseline to 1 year post-randomization among the three randomized HAART strategies in FIRST. The secondary objectives of this study are: 1) to compare changes over time in total cholesterol, triglycerides, waist circumference, and waist-to-hip ratio over time among the three randomized HAART strategies in the FIRST protocol; 2) to compare changes in body composition/habitus indicators; 3) to determine the association between changes in lipids and changes in the measurements; 4) to compare the use of cardiovascular agents and antidiabetic agents; 5) to compare survival and the incidence of angina pectoris, myocardial infarction, stroke, and diabetes mellitus.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。迫切需要精心设计的前瞻性研究来阐明与 HIV 感染和/或其治疗相关的代谢并发症的发生率、发病时间、病理生理学、预测因素和临床意义。因此，本方案的主要目标是比较 FIRST 中三种随机 HAART 策略从基线到随机化后 1 年的总胆固醇、甘油三酯、腰围和腰臀比的变化。本研究的次要目标是： 1) 比较 FIRST 方案中三种随机 HAART 策略中总胆固醇、甘油三酯、腰围和腰臀比随时间的变化； 2）比较身体成分/体态指标的变化； 3) 确定脂质变化与测量变化之间的关联； 4）比较心血管药物和抗糖尿病药物的使用情况； 5）比较生存率以及心绞痛、心肌梗塞、中风和糖尿病的发生率。