METABOLIC CONSEQUENCES OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) IN HIV

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an urgent need for well-designed, prospective studies to elucidate the incidence, time of onset, pathophysiology, predictors, and clinical significance of metabolic complications associated with HIV infection and/or its treatment. Therefore, the primary objective of this protocol is to compare changes in total cholesterol, triglycerides, waist circumference, and waist-to-hip ratio from baseline to 1 year post-randomization among the three randomized HAART strategies in FIRST. The secondary objectives of this study are: 1) to compare changes over time in total cholesterol, triglycerides, waist circumference, and waist-to-hip ratio over time among the three randomized HAART strategies in the FIRST protocol; 2) to compare changes in body composition/habitus indicators; 3) to determine the association between changes in lipids and changes in the measurements; 4) to compare the use of cardiovascular agents and antidiabetic agents; 5) to compare survival and the incidence of angina pectoris, myocardial infarction, stroke, and diabetes mellitus.