CPCRA 060: A PROSPECTIVE STUDY OF LONG-TERM CLINICAL, VIROLOGIC OUTCOMES IN HIV

CPRA 060：艾滋病毒长期临床病毒学结果的前瞻性研究

• 批准号: 7376246
• 负责人: DAVID M MUSCHATT
• 金额: $ 3.38万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376246
• 关键词: CPCRA; 060; PROSPECTIVE; STUDY; LONG

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to provide a mechanism for long-term monitoring of treatment or management strategies. The primary objective of the study is to compare rates of morbidity and mortality in participants randomized to different HIV treatment management strategies. The secondary objectives are: 1) to study the association of long-term virologic and immunologic changes with progression of HIV disease; 2) describe patterns of change in treatment over time and natural history; 3) to compare incidents of management strategies; 4) conduct studies for those who develop clinical events; 5) compare demographics and risk categories; 6) to determine relationships between genotypic patterns and clinical disease progression. This study will enroll about 4,000 patients and will take approximately five years to complete.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是提供一种长期监测治疗或管理策略的机制。这项研究的主要目标是比较被随机分配到不同艾滋病毒治疗管理策略的参与者的发病率和死亡率。次要目标是：1)研究长期病毒学和免疫学变化与艾滋病毒疾病进展的关系；2)描述治疗随时间和自然病史的变化模式；3)比较管理策略的事件；4)对出现临床事件的人进行研究；5)比较人口统计学和风险类别；6)确定基因模式与临床疾病进展之间的关系。这项研究将招募大约4000名患者，大约需要五年时间才能完成。