PROSPECTIVE EVALUATION OF ADULTS WITH THE ASEPTIC MENINGITIS SYNDROME

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to better identify which patients with meningitis are at low risk of having an urgent treatable cause accounting for their meningitis. The design of the study is to collect detailed information regarding the symptoms the patients have experienced, the findings on PE, the results of all labs, as well as pertinent information recorded in the hospital chart about any health problems. Available left over spinal fluid will be used to test for enteroviruses. No further spinal taps will be done. Blood will be drawn at baseline and at two weeks for testing for arboviruses. If no cause is found for the patient's episode of meningitis, other blood tests will be performed to check for other possible bacteria or viruses. Follow-up visits at the GCRC will be done at baseline, two weeks, four weeks and three months. At these visits, questions regarding symptoms, a neurological exam and blood will be done.