The impact of social evaluation on perception of facial affect in adults with social anxiety

社会评价对社交焦虑成人面部情感感知的影响

• 批准号: 10613913
• 负责人: Dana Elizabeth Diaz
• 金额: $ 1.19万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-25 至 2023-06-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10613913
• 关键词: Adult; Affect; Amygdaloid structure; Anger; Anterior; Anxiety; Anxiety Disorders; Arbitration; Attention; Auditory; Behavioral; Brain region; Color; Complex; Cues; Data; Detection; Dorsal; Emotional; Emotions; Etiology; Evaluation; Event; Experimental Designs; Face; Face Processing; Facial Expression; Fright; Functional Magnetic Resonance Imaging; Fusiform gyrus; Future; Happiness; Impairment; Individual; Intervention; Knowledge; Life; Measures; Mental Health; Modeling; Multivariate Analysis; Participant; Pattern; Perception; Persons; Population; Prefrontal Cortex; Process; Psychophysiology; Research; Sampling; Sensory; Shapes; Signal Transduction; Social Anxiety Disorder; Social Interaction; Social Perception; Source; Stimulus; Structure; Symptoms; Techniques; Testing; United States; Visual; Work; Youth; analytical method; anxiety symptoms; anxious individuals; area striata; behavior measurement; blood oxygenation level dependent response; cingulate cortex; ethnic diversity; insight; interest; negative affect; neural; neural circuit; neuroimaging; neuromechanism; response; social; social anxiety; social bias; social influence; social situation; social stressor; trait; vigilance; young adult

Project Summary/Abstract Social anxiety disorders are one of the most common and widely impairing mental health issues among adults in the United States. Social anxiety is characterized by anxiety from anticipation of aversive future social events. Elevations in such anticipatory anxiety may bias perception of threat stimuli through enhanced connections between the amygdala and visual sensory regions. Upon viewing threatening face stimuli, people with social anxiety display increased activity in perceptual and face-processing regions and increased connectivity between these regions and the amygdala, suggesting a possible etiological account for social anxiety disorders. However, current research examining the underlying neural origins of biased perception and its contributions to anxiety disorders suffers from important limitations. First, much of this work has focused on how attentional mechanisms increase vigilance to threat stimuli, and less is known about sensory representations of threat in visual circuitry. Second, the degree to which extant models of perceptual biases in anxiety are generalizable beyond white, middle SES adults is not known. Finally, most fMRI studies that investigate biases in emotion perception in social anxiety disorder have employed univariate analyses which do not characterize how information is represented in neural activity patterns, limiting inferences about how social anxiety might influence sensory representations of threat. In two aims, the proposed study will address these limitations by applying univariate, multivariate, and functional connectivity analyses, in an ethnically diverse sample of young adults with and without social anxiety. Aim 1 will test whether trait social anxiety influences neural and behavioral sensitivity to threat upon viewing ambiguous faces blended between threatening (fear/anger) and safe (happy) expressions. Aim 2 will test whether experimentally inducing anticipatory anxiety via a social threat influences neural and behavioral threat sensitivity. Signal detection theoretic metrics will measure behavioral threat sensitivity, or the degree of threat affect required for a face to be judged as fearful or angry. Univariate and multivariate measures of neural activity will characterize neural threat sensitivity in perceptual (V1, fusiform gyrus) and emotional (amygdala, anterior insular cortex, dorsal anterior cingulate cortex, dorsomedial prefrontal cortex, ventrolateral prefrontal cortex) brain regions. Functional connectivity analyses will probe the cortical networks underlying anticipatory anxiety in social anxiety. By inducing anticipatory anxiety, I can test whether social threat increases connectivity between the amygdala and perceptual regions and concomitantly alters multivoxel sensory representations of ambiguous facial affect, which has not yet been done. Together, these aims focus on an understudied but central feature of social anxiety disorders, builds on my knowledge of new multivariate analytic techniques and promises to provide new information about the neural mechanisms underlying social anxiety.

项目总结/摘要 社交焦虑症是成年人中最常见和最广泛损害心理健康的问题之一 在美国社交焦虑的特征是对未来社交活动的预期产生焦虑 事件这种预期焦虑的升高可能会通过增强对威胁刺激的感知而使其产生偏见。 杏仁核和视觉区域之间的联系。当人们看到威胁性的面部刺激时， 随着社交焦虑的显示，知觉和面孔处理区域的活动增加， 这些区域和杏仁核之间的连接，这表明一个可能的病因解释社会 焦虑症然而，目前的研究探讨了偏见感知的潜在神经起源， 它对焦虑症的作用受到重要的限制。首先，这项工作的大部分集中在 注意力机制如何提高对威胁刺激的警惕性，而对感官的了解较少 视觉回路中的威胁表征。第二，在多大程度上现存的模型的知觉偏见， 焦虑是普遍超过白色，中间SES成人是未知的。最后，大多数功能磁共振成像研究， 对社交焦虑障碍患者情绪感知偏差的研究采用了单变量分析， 没有描述信息是如何在神经活动模式中表现的，限制了关于如何表现的推断。 社交焦虑可能影响威胁的感觉表征。在两个目标中，拟议的研究将解决 通过应用单变量，多变量和功能连接分析，在种族上 有和没有社交焦虑的年轻人样本。目标1将测试特质社交焦虑是否 影响神经和行为的敏感性，以威胁时，看到模糊的面孔混合在 威胁（恐惧/愤怒）和安全（快乐）的表达。目标2将测试是否通过实验诱导 预期焦虑通过社会威胁影响神经和行为的威胁敏感度。信号检测 理论度量将测量行为威胁敏感度，或威胁影响的程度， 被认为是恐惧或愤怒。神经活动的单变量和多变量测量将表征神经 知觉（V1，梭状回）和情感（杏仁核，前岛叶皮层，背侧）的威胁敏感性 前扣带皮层、背内侧前额叶皮层、腹外侧前额叶皮层）脑区域。 功能连接分析将探索社交焦虑中潜在的皮层网络。 焦虑通过诱导预期焦虑，我可以测试社会威胁是否会增加 杏仁核和知觉区，并伴随改变多体素的感觉表征的模糊 面部表情，这还没有完成。总之，这些目标集中在一个研究不足但核心的特征上 社交焦虑症，建立在我对新的多元分析技术的知识，并承诺 为社交焦虑的神经机制提供了新的信息。