PANCREATIC ISLET CELL FUNCTION AND GLUCOSE TOLERANCE FOLLOWING TRANSPLANT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。胰腺切除术是治疗慢性胰腺炎相关疼痛综合征的一种方法。这会导致严重的糖尿病，因为胰腺内分泌功能丧失。在手术时分离胰岛，并将这些含有胰岛素的细胞返回，即自体胰岛移植，是减轻与胰腺切除相关的糖尿病的一种实验性方法。以前的工作已经证实，这种方法可以在预防糖尿病方面取得良好的结果，但尚不清楚自体移植后胰岛功能持续多久。这项研究旨在评估患者自体胰岛移植前后的情况，以确定他们分泌胰岛素和控制血糖的能力。受试者在注射精氨酸后和口服葡萄糖耐量试验期间测量胰岛素分泌。在术后6个月、12个月、24个月和36个月重复这些测试，以确定胰岛移植物随时间的功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pancreatectomy is one approach to treating the pain syndrome associated with chronic pancreatitis. This leads to severe diabetes because of loss of pancreatic endocrine function. Isolation of the pancreatic islets at the time of surgery and return of these insulin containing cells, islet autotransplantation, is an experimental means of mitigating the diabetes associated with pancreatectomy. Previous work has established that this approach can lead to good outcomes with prevention of diabetes but it is not clear how long islet function persists after autotransplant. This study is designed to evaluate patients before and serially after islet autotransplant to determine their ability to secrete insulin and control their blood glucose. Subjects have insulin secretion measured after an infusion of arginine and during an oral glucose tolerance test. These tests are repeated at 6, 12, 24 and 36 months after surgery to determine the function of the islet grafts over time.