PANCREATIC ISLET CELL FUNCTION AND GLUCOSE TOLERANCE FOLLOWING TRANSPLANT

移植后的胰岛细胞功能和葡萄糖耐量

• 批准号: 7607727
• 负责人: DAVID A. D'ALESSIO
• 金额: $ 1.11万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607727
• 关键词: Arginine; Autologous Transplantation; Blood Glucose; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diabetes prevention; Endocrine; Funding; Grant; Infusion procedures; Institution; Insulin; Islet Cell; Islets of Langerhans; Lead; Measures; OGTT; Operative Surgical Procedures; Outcome; Pain; Pancreas; Pancreatectomy; Patients; Research; Research Personnel; Resources; Source; Syndrome; Testing; Time; Transplantation; United States National Institutes of Health; Work; chronic pancreatitis; design; glucose tolerance; insulin secretion; islet

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pancreatectomy is one approach to treating the pain syndrome associated with chronic pancreatitis. This leads to severe diabetes because of loss of pancreatic endocrine function. Isolation of the pancreatic islets at the time of surgery and return of these insulin containing cells, islet autotransplantation, is an experimental means of mitigating the diabetes associated with pancreatectomy. Previous work has established that this approach can lead to good outcomes with prevention of diabetes but it is not clear how long islet function persists after autotransplant. This study is designed to evaluate patients before and serially after islet autotransplant to determine their ability to secrete insulin and control their blood glucose. Subjects have insulin secretion measured after an infusion of arginine and during an oral glucose tolerance test. These tests are repeated at 6, 12, 24 and 36 months after surgery to determine the function of the islet grafts over time.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 胰腺切除术是治疗与慢性胰腺炎相关的疼痛综合征的一种方法。 由于胰腺内分泌功能丧失，这会导致严重的糖尿病。在手术时分离胰岛并返回这些含有胰岛素的细胞，即胰岛自体移植，是减轻与胰腺切除术相关的糖尿病的一种实验方法。之前的研究已经证实，这种方法可以在预防糖尿病方面取得良好的效果，但尚不清楚自体移植后胰岛功能能持续多久。本研究旨在评估胰岛自体移植之前和之后的患者，以确定他们分泌胰岛素和控制血糖的能力。在输注精氨酸后和在口服葡萄糖耐量测试期间测量受试者的胰岛素分泌。这些测试在术后 6、12、24 和 36 个月重复进行，以确定胰岛移植物随时间的功能。